ArticleThe Journal of experimental biology2022
Integrating theoretical and empirical approaches for a robust understanding of endocrine flexibility.
Article in The Journal of experimental biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Same species, different risks: predation shapes hormonal profiles in a breeding sea duck, the common eider.Conservation physiology · 2026Article
- Physiological Responses Vary with Molecular Damage Outcomes after Recovery from Constant Light.Integrative and comparative biology · 2025Article
- Endocrine flexibility can facilitate or constrain the ability to cope with global change.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Modelling the role of glucocorticoid receptor as mediator of endocrine responses to environmental challenge.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- HPA flexibility andPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Climate change and its effects on body size and shape: the role of endocrine mechanisms.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Endocrine responses to environmental variation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Social buffering of the stress response: insights from fishes.Biology letters · 2022Review
- Optimal hormonal regulation when stressor cues are imperfect.Hormones and behavior · 2022Article
- Bidirectional relationships between testosterone and aggression: a critical analysis of four predictions.Integrative and comparative biology · 2022Article
- Misaligned hormonal rhythmicity: Mechanisms of origin and their clinical significance.Journal of neuroendocrinology · 2022Review
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Authors and funding
4 authors.
Funding
Abstract
There is growing interest in studying hormones beyond single 'snapshot' measurements, as recognition that individual variation in the endocrine response to environmental change may underlie many rapid, coordinated phenotypic changes. Repeated measures of hormone levels in individuals provide additional insight into individual variation in endocrine flexibility - that is, how individuals modulate hormone levels in response to the environment. The ability to quickly and appropriately modify phenotype is predicted to be favored by selection, especially in unpredictable environments. The need for repeated samples from individuals can make empirical studies of endocrine flexibility logistically challenging, but methods based in mathematical modeling can provide insights that circumvent these challenges. Our Review introduces and defines endocrine flexibility, reviews existing studies, makes suggestions for future empirical work, and recommends mathematical modeling approaches to complement empirical work and significantly advance our understanding. Mathematical modeling is not yet widely employed in endocrinology, but can be used to identify innovative areas for future research and generate novel predictions for empirical testing.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.