Evidence map›Paper›PMID 35262397›Full record

ReviewStem cells and development2022

Adipose-Derived Stromal/Stem Cell Response to Tumors and Wounds: Evaluation of Patient Age.

Katie M Hamel, Kara Q Liimatta, Jorge A Belgodere, Bruce A Bunnell, Jeffrey M Gimble, Elizabeth C Martin

Open access · greenAbstract readReview
In one paragraph

Review in Stem cells and development, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. [Experimental study on promotion of skin radiation damage repair by icarin via HIF-2α/VEGF/Notch pathway to enhance the paracrine function of adipose-derived stem cells].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025
    Article
  2. Article
  3. Review
  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Katie M HamelDepartment of Biological Engineering, Louisiana State University, Baton Rouge, Louisiana, USA.
Kara Q LiimattaDepartment of Biological Engineering, Louisiana State University, Baton Rouge, Louisiana, USA.
Jorge A BelgodereDepartment of Biological Engineering, Louisiana State University, Baton Rouge, Louisiana, USA.
Bruce A BunnellUniversity of North Texas Health Sciences Center, Fort Worth, Texas, USA.ORCID 0000-0001-6196-3722
Jeffrey M GimbleObatala Sciences, Inc., New Orleans, Louisiana, USA.
Elizabeth C MartinDepartment of Biological Engineering, Louisiana State University, Baton Rouge, Louisiana, USA.
Louisiana State University · USUniversity of New Orleans · USUniversity of North Texas · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Peter Todd Katzmarzyk · 2012 to 2026
$69.1M
NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

Tumors were characterized as nonhealing wounds by Virchow in 1858 and Dvorak in 1986. Since then, researchers have analyzed tumors from a new perspective. The parallels between tumorigenesis and physiological wound healing can provide a new framework for developing antitumor therapeutics. One commonality between tumors and wounds is the involvement of the stromal environment, particularly adipose stromal/stem cells (ASCs). ASCs exhibit dual functions, in which they stimulate tumor progression and assist in tissue repair and regeneration. Numerous studies have focused on the role of ASCs in cancer and wound healing, but none to date has linked age, cancer, and wound healing. Furthermore, very few studies have focused on the role of donor-specific characteristics of ASCs, such as age and their role in facilitating ASC behavior in cancer and wound healing. This review article is designed to provide important insights into the impact of donor age on ASC tumor and wound response and their role in facilitating ASC behavior in cancer and wound healing.

Indexed as

Adipose TissueNeoplasmsHumansStem CellsStromal CellsWound Healingadipose-derived stromal/stem cells (ASCs)keloid scarstumor microenvironment (TME)wound healing

Identifiers

PMID35262397
PMCPMC9836707
OpenAlexW4221061389

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.