ArticleActa radiologica (Stockholm, Sweden : 1987)2023
Hepatic enhancement at computed tomography: is there a dependence on body weight past institutional contrast dosing limits?
Article in Acta radiologica (Stockholm, Sweden : 1987), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 1 citations in OpenAlex.
- Optimization of high-concentration (400 mgI/mL) contrast media volume for abdominal computed tomography: a comparison between fixed-dose and total body weight-based protocols.Quantitative imaging in medicine and surgery · 2026Article
- Validation of a multi-parameter algorithm for personalized contrast injection protocol in liver CT.European radiology experimental · 2024Article
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4 authors at 2 institutions in 1 country.
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Abstract
backgroundAlthough described in product monographs, the maximum contrast media (CM) dose at computed tomography (CT) varies among institutions. PURPOSE: To investigate whether an upper limit of 40 g of iodine in women and 50 g in men is sufficient or if there is a body weight (BW) dependence of mean hepatic enhancement (MHE) beyond those thresholds. MATERIAL AND
methodsAt our institution, CM injection duration is fixed to 30 s and dosed 600 mg iodine/kg up to 40 g in women and 50 g in men. Pre- and post-contrast hepatic attenuation values (HU) were retrospectively obtained in 200 women and 200 men with glomerular filtration rate >45 mL/min undergoing 18-flurodeoxyglucose PET-CT (18F-FDG PET-CT) of which half weighed below and half above those dose thresholds using iodixanol 320 mg iodine/mL or iomeprol 400 mg iodine/mL. The correlation between BW and MHE was assessed by simple linear regression.
resultsWeight range was 41-120 kg in women and 47-137 kg in men. There was no significant relationship between MHE and BW in women receiving <40 g (r = -0.05,
conclusionAdjusting CM to BW diminishes the dependence of MHE on BW. There was no apparent upper limit for the relationship between BW and MHE in heavier patients at CM-enhanced CT.
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