ArticleMolecular pain
Single-nucleotide polymorphisms of the SLC17A9 and P2RY12 genes are significantly associated with phantom tooth pain.
Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 9 citations in OpenAlex.
- Investigation of Genetic Polymorphisms in Inducible Nitric Oxide Synthase and Suppressor of Cytokine Signaling Genes and Pain After Root Canal Treatment.Biochemical genetics · 2026Article
- Exocytosed ATP as a therapeutic target for inflammatory and metabolic diseases.Frontiers in pharmacology · 2026Review
- Lysosomal Ion Channels and Transporters: Recent Findings, Therapeutic Potential, and Technical Approaches.Bioelectricity · 2025Review
- What Do We Know about Nociplastic Pain?Healthcare (Basel, Switzerland) · 2023Review
- Targeted Therapy for Orofacial Pain: A Novel Perspective for Precision Medicine.Journal of personalized medicine · 2023Review
- The rs216009 single-nucleotide polymorphism of theMolecular painArticle
- rs12411980 single-nucleotide polymorphism related toMolecular painArticle
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
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Abstract
Phantom tooth pain (PTP) is a rare and specific neuropathic pain that occurs after pulpectomy and tooth extraction, but its cause is not understood. We hypothesized that there is a genetic contribution to PTP. We focused on solute carrier family 17 member 9 (SLC17A9)/vesicular nucleotide transporter (VNUT) and purinergic receptor P2Y12 (P2RY12), both of which have been associated with neuropathic pain and pain transduction signaling in the trigeminal ganglion in rodents. We sought to corroborate these associations in humans. We investigated gene polymorphisms that contribute to PTP. We statistically examined the association between genetic polymorphisms and PTP vulnerability in 150 patients with orofacial pain, including PTP, and 500 healthy subjects. We found that the rs735055 polymorphism of the
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