Evidence map›Paper›PMID 35267604›Full record

ReviewCancers2022

Liver Transplantation for Pediatric Hepatocellular Carcinoma: A Systematic Review.

Christos D Kakos, Ioannis A Ziogas, Charikleia D Demiri, Stepan M Esagian, Konstantinos P Economopoulos, Dimitrios Moris, Georgios Tsoulfas, Sophoclis P Alexopoulos

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
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  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Christos D KakosSurgery Working Group, Society of Junior Doctors, 15123 Athens, Greece.ORCID 0000-0002-2269-9014
Ioannis A ZiogasSurgery Working Group, Society of Junior Doctors, 15123 Athens, Greece.ORCID 0000-0002-6742-6909
Charikleia D DemiriSurgery Working Group, Society of Junior Doctors, 15123 Athens, Greece.ORCID 0000-0002-5798-4712
Stepan M EsagianSurgery Working Group, Society of Junior Doctors, 15123 Athens, Greece.ORCID 0000-0002-7602-862X
Konstantinos P EconomopoulosSurgery Working Group, Society of Junior Doctors, 15123 Athens, Greece.
Dimitrios MorisDepartment of Surgery, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0002-5276-0699
Georgios TsoulfasDepartment of Surgery, Aristotle University School of Medicine, 54124 Thessaloniki, Greece.ORCID 0000-0001-5043-7962
Sophoclis P AlexopoulosDepartment of Surgery, Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Duke Medical Center · USVanderbilt University Medical Center · USAristotle University of Thessaloniki · GRPapageorgiou General Hospital · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver transplantation (LT) is the only potentially curative option for children with unresectable hepatocellular carcinoma (HCC). We performed a systematic review of the MEDLINE, Scopus, Cochrane Library, and Web of Science databases (end-of-search date: 31 July 2020). Our outcomes were overall survival (OS) and disease-free survival (DFS). We evaluated the effect of clinically relevant variables on outcomes using the Kaplan-Meier method and log-rank test. Sixty-seven studies reporting on 245 children undergoing LT for HCC were included. DFS data were available for 150 patients and the 1-, 3-, and 5-year DFS rates were 92.3%, 89.1%, and 84.5%, respectively. Sixty of the two hundred and thirty-eight patients (25.2%) died over a mean follow up of 46.8 ± 47.4 months. OS data were available for 222 patients and the 1-, 3-, and 5-year OS rates were 87.9%, 78.8%, and 74.3%, respectively. Although no difference was observed between children transplanted within vs. beyond Milan criteria (

Indexed as

fibrolamellarHCChepatocellular carcinomahepatomaliver transplantationliving donorMilan criteriapediatric

Identifiers

PMID35267604
PMCPMC8908995
OpenAlexW4214898876

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.