Evidence map›Paper›PMID 35269644›Full record

ArticleInternational journal of molecular sciences2022

Monitoring TRPC7 Conformational Changes by BRET Following GPCR Activation.

Cécile Pétigny, Audrey-Ann Dumont, Hugo Giguère, Audrey Collette, Brian J Holleran, Mircea Iftinca, Christophe Altier, Élie Besserer-Offroy, Mannix Auger-Messier, Richard Leduc

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. CaBiomedicines · 2025
    Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Cécile PétignyDepartment of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Audrey-Ann DumontInstitut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Hugo GiguèreInstitut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.ORCID 0000-0001-7193-0051
Audrey ColletteDepartment of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Brian J HolleranDepartment of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Mircea IftincaDepartment of Physiology and Pharmacology, Inflammation Research Network-Snyder Institute for Chronic Diseases and Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB T2N 1N4, Canada.
Christophe AltierDepartment of Physiology and Pharmacology, Inflammation Research Network-Snyder Institute for Chronic Diseases and Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB T2N 1N4, Canada.ORCID 0000-0003-2209-6536
Élie Besserer-OffroyDepartment of Molecular and Medical Pharmacology, Ahmanson Translational Theranostics Division, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-7473-7043
Mannix Auger-MessierInstitut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.
Richard LeducDepartment of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.ORCID 0000-0001-6854-8003
Université de Sherbrooke · CAUniversity of Calgary · CACalifornia NanoSystems Institute · US

Funding

CIHR Project grant - MOP
6 · The paper itself

Abstract

Transient receptor potential canonical (TRPC) channels are membrane proteins involved in regulating Ca

Indexed as

Bioluminescence Resonance Energy Transfer TechniquesBiosensing TechniquesAnimalsHEK293 CellsHumansRatsReceptor, Angiotensin, Type 1TRPC Cation ChannelsReceptor, Angiotensin, Type 1TRPC7 protein, humanTRPC Cation ChannelsAngiotensin II (AngII)Angiotensin II type-1 receptor (AT1R)bioluminescence resonance energy transfer (BRET)cellular signalingG protein alpha q subunitG protein-coupled receptor (GPCR)transient receptor potential canonical (TRPC)

Identifiers

PMID35269644
PMCPMC8910688
OpenAlexW4214547528

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.