ArticleNeuroImage2022
Higher-order multi-shell diffusion measures complement tensor metrics and volume in gray matter when predicting age and cognition.
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Age-related differences in hippocampal subfield volumes across the human lifespan: A meta-analysis.Hippocampus · 2023Pooled it
- Contributions of Gray Matter Microstructure to Differences in Fluid Cognition and Episodic Memory Across the Healthy Adult Lifespan.Human brain mapping · 2026Article
- Subcortical correlates of developmental language disorder: more than the neostriatum.Brain communications · 2026Article
- Cognitive Strategy Accounts for Failure on a Relational Memory Task in Non-Human Primates.Hippocampus · 2026Article
- Longitudinal non-linear changes in the microstructure of the hippocampal subfields in older adults.Neurobiology of aging · 2025Article
- General Microstructure Factor Analysis of Diffusion MRI in Gray-Matter Predicts Cognitive Scores.ArXiv · 2025Article
- Article
- Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder.NPJ Parkinson's disease · 2025Article
- Aging of gray matter microstructure: A brain-wide characterization of age group differences using NODDI.Neurobiology of aging · 2025Article
- NODDI-derived measures of microstructural integrity in medial temporal lobe white matter pathways are associated with Alzheimer's disease pathology and cognition.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Advanced diffusion imaging in grey matter reflects individual differences in cognitive ability in older adults.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- APOE4 Increases Susceptibility to Amyloid, Accelerating Episodic Memory Decline.bioRxiv : the preprint server for biology · 2024Article
- Spatial and temporal patterns of cortical mean diffusivity in Alzheimer's disease and suspected non-Alzheimer's disease pathophysiology.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Cognitive modeling of the Mnemonic Similarity Task as a digital biomarker for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Cerebral microstructural alterations in Post-COVID-condition are related to cognitive impairment, olfactory dysfunction and fatigue.Nature communications · 2024Article
- Age-Related Brain Atrophy and the Positive Effects of Behavioral Enrichment in Middle-Aged Beagles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cognitive modeling of the Mnemonic Similarity Task as a digital biomarker for Alzheimer's Disease.bioRxiv : the preprint server for biology · 2024Article
- Circulating PACAP levels are associated with altered imaging measures of entorhinal cortex neurite density in posttraumatic stress disorder.European journal of psychotraumatology · 2024Article
- TractoSCR: a novel supervised contrastive regression framework for prediction of neurocognitive measures using multi-site harmonized diffusion MRI tractography.Frontiers in neuroscience · 2024Article
- High-resolution multi-shot diffusion imaging of structural networks in healthy neurocognitive aging.NeuroImage · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Recent advances in diffusion-weighted imaging have enabled us to probe the microstructure of even gray matter non-invasively. However, these advanced multi-shell protocols are often not included in large-scale studies as they significantly increase scan time. In this study, we investigated whether one set of multi-shell diffusion metrics commonly used in gray matter (as derived from Neurite Orientation Dispersion and Density Imaging, NODDI) provide enough additional information over typical tensor and volume metrics to justify the increased acquisition time, using the cognitive aging framework in the human hippocampus as a testbed. We first demonstrated that NODDI metrics are robust and reliable by replicating previous findings from our lab in a larger population of 79 younger (20.41 ± 1.89 years, 46 females) and 75 older (73.56 ± 6.26 years, 45 females) adults, showing that these metrics in the hippocampal subfields are sensitive to age and memory performance. We then asked how these subfield specific hippocampal NODDI metrics compared with standard tensor metrics and volume in predicting age and memory ability. We discovered that both NODDI and tensor measures separately predicted age and cognition in comparable capacities. However, integrating these modalities together considerably increased the predictive power of our logistic models, indicating that NODDI and tensor measures may be capturing independent microstructural information. We use these findings to encourage neuroimaging data collection consortiums to include a multi-shell diffusion sequence in their protocols since existing NODDI measures (and potential future multi-shell measures) may be able to capture microstructural variance that is missed by traditional approaches, even in studies exclusively examining gray matter.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.