ArticleNature communications2022
A comprehensive temporal patterning gene network in Drosophila medulla neuroblasts revealed by single-cell RNA sequencing.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 63 citations in OpenAlex.
- Tailless terminates the neural stem cell temporal cascade in both the optic lobe and central brain.Development (Cambridge, England) · 2026Article
- A developmental single-cell atlas of the Drosophila visual system glia reveals cell type diversification and subcellular mRNA compartmentalization.PLoS biology · 2026Article
- The microcephaly protein Abnormal Spindle has an essential role in symmetrically dividing neural precursors to promote brain growth and development.Developmental biology · 2026Article
- Modern Mining: The Role of Single-cell RNA Sequencing in Advancing Neuroscience Research.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Spatial, temporal and Notch determination of terminal selector expression controls neuronal cell fate in the Drosophila optic lobe.Nature neuroscience · 2026Article
- Temporal and Notch identity determine neuropil targeting depth and synapse location in the fly visual system.bioRxiv : the preprint server for biology · 2026Article
- Regulatory logic of neuronal identity specification inbioRxiv : the preprint server for biology · 2025Article
- Multilayer regulation underlies the functional precision and evolutionary potential of the olfactory system.Nature communications · 2025Article
- Concurrent temporal patterning of neural stem cells in the fly visual system.Nature communications · 2025Article
- Decoding neuronal diversity: Mechanisms governing neural cell fate in Drosophila.Current opinion in neurobiology · 2025Review
- Applications and techniques of single-cell RNA sequencing across diverse species.Briefings in bioinformatics · 2025Review
- Analysis of molecular and cellular bases of honey bee mushroom body development.Scientific reports · 2025Article
- In vivo AGO-APP identifies a module of microRNAs cooperatively preserving neural progenitors.PLoS genetics · 2025Article
- Gene trajectory inference for single-cell data by optimal transport metrics.Nature biotechnology · 2025Article
- Morphological and functional convergence of visual projection neurons from diverse neurogenic origins in Drosophila.Nature communications · 2025Article
- Article
- MATES: a deep learning-based model for locus-specific quantification of transposable elements in single cell.Nature communications · 2024Article
- Article
- Spatial patterning controls neuron numbers in the Drosophila visual system.Developmental cell · 2024Article
- SiFT: uncovering hidden biological processes by probabilistic filtering of single-cell data.Nature communications · 2024Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
During development, neural progenitors are temporally patterned to sequentially generate a variety of neural types. In Drosophila neural progenitors called neuroblasts, temporal patterning is regulated by cascades of Temporal Transcription Factors (TTFs). However, known TTFs were mostly identified through candidate approaches and may not be complete. In addition, many fundamental questions remain concerning the TTF cascade initiation, progression, and termination. In this work, we use single-cell RNA sequencing of Drosophila medulla neuroblasts of all ages to identify a list of previously unknown TTFs, and experimentally characterize their roles in temporal patterning and neuronal specification. Our study reveals a comprehensive temporal gene network that patterns medulla neuroblasts from start to end. Furthermore, the speed of the cascade progression is regulated by Lola transcription factors expressed in all medulla neuroblasts. Our comprehensive study of the medulla neuroblast temporal cascade illustrates mechanisms that may be conserved in the temporal patterning of neural progenitors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.