ArticleDiabetologia2022
High-intensity interval training for 12 weeks improves cardiovascular autonomic function but not somatosensory nerve function and structure in overweight men with type 2 diabetes.
Article in Diabetologia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Effects of high-intensity interval training and moderate-intensity continuous training on type 2 diabetes mellitus: a meta-analysis and systematic review.Frontiers in endocrinology · 2026Pooled it
- Effect of exercise training on cardiac autonomic function in type 2 diabetes mellitus: a systematic review and meta-analysis.Systematic reviews · 2025Pooled it
- Meta-analysis of high-intensity interval training effects on cognitive function in older adults and cognitively impaired patients.Frontiers in physiology · 2025Pooled it
- The effects of high-intensity interval training on glucose metabolism, inflammatory responses, and functional recovery in patients with diabetic peripheral neuropathy.Frontiers in endocrinology · 2026Trial
- Six weeks of high-intensity interval training improve autonomic and metabolic responses in active postmenopausal women.Experimental physiology · 2026Article
- The autonomic nervous system in the regulation of glucose and lipid metabolism.Nature reviews. Endocrinology · 2026Review
- Cardiovascular autonomic dysfunction precedes cardiovascular disease and all-cause mortality: 11-year follow-up in the ADDITION-PRO study.Diabetes, obesity & metabolism · 2025Article
- Effectiveness of Physical Exercise on Indicators of Metabolic Syndrome in Adults: A Systematic Review with Meta-Analysis of Clinical Trials.Journal of functional morphology and kinesiology · 2025Review
- Interventional effects of exercise on neuropathy in patients with diabetes: a systematic review with meta-analysis.BMC sports science, medicine & rehabilitation · 2025Article
- An integrative review of the effects of high-intensity interval training on the autonomic nervous system.Sports medicine and health science · 2025Review
- The global and regional burden of diabetic peripheral neuropathy.Nature reviews. Neurology · 2025Review
- Article
- New perspectives in diabetic neuropathy.Neuron · 2023Review
- The conundrum of diabetic neuropathies-Past, present, and future.Journal of diabetes and its complications · 2022Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisIt remains unclear whether and which modality of exercise training as a component of lifestyle intervention may exert favourable effects on somatosensory and autonomic nerve tests in people with type 2 diabetes.
methodsCardiovascular autonomic and somatosensory nerve function as well as intraepidermal nerve fibre density (IENFD) were assessed in overweight men with type 2 diabetes (type 2 diabetes, n = 20) and male glucose-tolerant individuals (normal glucose tolerance [NGT], n = 23), comparable in age and BMI and serving as a control group, before and after a supervised high-intensity interval training (HIIT) intervention programme over 12 weeks. Study endpoints included clinical scores, nerve conduction studies, quantitative sensory testing, IENFD, heart rate variability, postural change in systolic blood pressure and spontaneous baroreflex sensitivity (BRS).
resultsAfter 12 weeks of HIIT, resting heart rate decreased in both groups ([mean ± SD] baseline/12 weeks: NGT: 65.1 ± 8.2/60.2 ± 9.0 beats per min; type 2 diabetes: 68.8 ± 10.1/63.4 ± 7.8 beats per min), while three BRS indices increased (sequence analysis BRS: 8.82 ± 4.89/14.6 ± 11.7 ms CONCLUSIONS/
interpretationIn male overweight individuals with type 2 diabetes, BRS, resting heart rate and orthostatic blood pressure regulation improved in the absence of weight loss after 12 weeks of supervised HIIT. Since no favourable effects on somatic nerve function and structure were observed, cardiovascular autonomic function appears to be more amenable to this short-term intervention, possibly due to improved cardiorespiratory fitness.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.