Evidence map›Paper›PMID 35277137›Full record

ArticleThe journal of physiological sciences : JPS2022

Mouse aortic biomechanics are affected by short-term defective autophagy in vascular smooth muscle cells.

Dorien G De Munck, Arthur J A Leloup, Sofie De Moudt, Guido R Y De Meyer, Wim Martinet, Paul Fransen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physiological sciences : JPS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dorien G De MunckLaboratory of Physiopharmacology, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.ORCID http://orcid.org/0000-0002-5506-5392
Arthur J A LeloupLaboratory of Physiopharmacology, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.ORCID http://orcid.org/0000-0003-2014-3618
Sofie De MoudtLaboratory of Physiopharmacology, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.ORCID http://orcid.org/0000-0003-0060-128X
Guido R Y De MeyerLaboratory of Physiopharmacology, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.ORCID http://orcid.org/0000-0003-3848-8702
Wim MartinetLaboratory of Physiopharmacology, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.ORCID http://orcid.org/0000-0003-1967-9343
Paul FransenLaboratory of Physiopharmacology, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium. fysiofarmacologie@uantwerpen.be.ORCID http://orcid.org/0000-0002-4577-3416
University of Antwerp · BE

Funding

BOF - University of Antwerp SEP 4177FWO G.0412.16NGOA - University of Antwerp 41667GOA-University of Antwerp GOA project 33931iBOF - University of Antwerp 21-053
6 · The paper itself

Abstract

The physiology of vascular smooth muscle (VSMC) cells is affected by autophagy, a catabolic cellular mechanism responsible for nutrient recycling. Autophagy-inducing compounds may reverse arterial stiffening, whereas congenital VSMC-specific autophagy deficiency promotes arterial stiffening. The elevated aortic stiffness in 3.5-month-old C57Bl/6 mice, in which the essential autophagy-related gene Atg7 was specifically deleted in the VSMCs (Atg7

Indexed as

Muscle, Smooth, VascularPulse Wave AnalysisAnimalsAutophagyBiomechanical PhenomenaMiceMice, Inbred C57BLArterial stiffnessAutophagyMouse aortaVascular smooth muscle cells

Identifiers

PMID35277137
PMCPMC10717727
OpenAlexW4220801272

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.