Evidence map›Paper›PMID 35283771›Full record

ArticleFrontiers in physiology2022

Effects of Postprandial Lipemia Combined With Disturbed Blood Flow on the Flow-Mediated Dilation, Oxidative Stress, and Endothelial Microvesicles in Healthy Subjects.

Gustavo S M Araujo, Thiago O C Silva, Grazia M Guerra, João E Izaias, Helena M N Rocha, Diego Faria, Natalia G Rocha, Aline Lopes Dalmazo, Amanda Araujo, Fernanda Marciano Consolim-Colombo and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Gustavo S M AraujoHeart Institute, University of São Paulo Medical School, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.
Thiago O C SilvaHeart Institute, University of São Paulo Medical School, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.
Grazia M GuerraHeart Institute, University of São Paulo Medical School, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.
João E IzaiasD'OR Institute for Research and Education, São Paulo, Brazil.
Helena M N RochaDepartment of Physiology and Pharmacology, Fluminense Federal University, Niterói, Brazil.
Diego FariaD'OR Institute for Research and Education, São Paulo, Brazil.
Natalia G RochaDepartment of Physiology and Pharmacology, Fluminense Federal University, Niterói, Brazil.
Aline Lopes DalmazoCardiology Institute of Rio Grande do Sul/Cardiology University Foundation (IC-FUC), Porto Alegre, Brazil.
Amanda AraujoDepartment of Physiology, Federal University of São Paulo, São Paulo, Brazil.
Fernanda Marciano Consolim-ColomboHeart Institute, University of São Paulo Medical School, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.
Katia de AngelisDepartment of Physiology, Federal University of São Paulo, São Paulo, Brazil.
Maria C C IrigoyenHeart Institute, University of São Paulo Medical School, Universidade Nove de Julho (UNINOVE), São Paulo, Brazil.
Allan R K SalesD'OR Institute for Research and Education, São Paulo, Brazil.
D’Or Institute for Research and Education · BRUniversidade Nove de Julho · BRUniversidade de São Paulo · BRUniversidade Federal de São Paulo · BRUniversidade Federal Fluminense · BRFundação Universitária de Cardiologia · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Both postprandial lipemia (PPL) and disturbed blood flow (DBF) induce endothelial dysfunction. However, the interactive effect of these stimuli on endothelial function is currently unknown. In the present study, we tested whether PPL plus DBF causes a greater reduction in flow-mediated dilation (FMD) than PPL and if this response is associated with elevations in oxidative stress and endothelial microvesicles (EMVs). Methods: Eighteen individuals (aged 28 ± 1yrs, 3 females, and BMI 24.43 ± 0.8kg/m Results: Hypertriglyceridemia was observed in both sessions. Retrograde shear rate and oscillatory index responses were significantly higher in the PPL plus DBF compared with PPL. PPL plus DBF evoked a greater reduction in FMD than did PPL and EMVs, NADPH oxidase, and H Conclusion: These data indicate that the association of PPL plus DBF additively impairs endothelium-dependent function in 110 min after stimulus in healthy individuals, despite a similar increase in oxidative stress and EMVs. Further studies are needed to understand the mechanisms associated with the induced-endothelial dysfunction by association of PPL and DBF.

Indexed as

disturbance in blood flow patternsendothelial functionendothelial microvesiclesoxidative stresspostprandial lipemia

Identifiers

PMID35283771
PMCPMC8907728
OpenAlexW4213425510

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.