Evidence map›Paper›PMID 35283773›Full record

ReviewFrontiers in physiology2022

New Insights Into Energy Substrate Utilization and Metabolic Remodeling in Cardiac Physiological Adaption.

Xiaomeng Shi, Hongyu Qiu

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
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  15. Metabolic Adaptation in Epilepsy: From Acute Response to Chronic Impairment.International journal of molecular sciences · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Xiaomeng ShiCenter for Molecular and Translational Medicine, Institute of Biomedical Sciences, Georgia State University, Atlanta, GA, United States.
Hongyu QiuCenter for Molecular and Translational Medicine, Institute of Biomedical Sciences, Georgia State University, Atlanta, GA, United States.
Georgia State University · US

Funding

Intrinsic Stiffness of Aortic Vascular Smooth Muscle Cell in the Development of HypertensionR01HL115195 · NHLBI · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI QIU, HONGYU · 2013 to 2022
$5.1M
Role of VCP in coronary ischemic injuryR01HL142291 · NHLBI · LOMA LINDA UNIVERSITY · PI QIU, HONGYU, XIE, ZHONGLIN · 2018 to 2021
$2.6M
Novel mechanism mediating cardiac protection upon pressure overloadR01HL137962 · NHLBI · LOMA LINDA UNIVERSITY · PI QIU, HONGYU · 2018 to 2020
$1.2M
Novel mechanisms mediating cardiac protection upon pressure overloadR56HL137962 · NHLBI · LOMA LINDA UNIVERSITY · PI QIU, HONGYU · 2017 to 2017
$393k
NHLBI NIH HHS R01 HL115195NHLBI NIH HHS R01 HL137962NHLBI NIH HHS R01 HL142291NHLBI NIH HHS R56 HL137962
6 · The paper itself

Abstract

Cardiac function highly relies on sufficient energy supply. Perturbations in myocardial energy metabolism play a causative role in cardiac pathogenesis. Accumulating evidence has suggested that modifications of cardiac metabolism are also an essential part of the adaptive responses to various physiological conditions in the heart to meet specific energy needs. The review highlighted some new studies on basic myocardial energy substrate metabolism and updated recent findings regarding cardiac metabolic remodeling and their associated mechanisms under physiological conditions, including exercise and cardiac development. Studying basic metabolic profiles in the heart in these conditions can contribute to understanding the significance of metabolic regulation in the heart during physiological adaption and gaining further insights into the maladaptive metabolic changes associated with cardiac pathogenesis, thus opening up new avenues to exploring novel therapeutic strategies in cardiac diseases.

Indexed as

cardiac diseaseheartmetabolismphysiologysubstrate utilization

Identifiers

PMID35283773
PMCPMC8914108
OpenAlexW4214567862

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.