Evidence map›Paper›PMID 35285483›Full record

ArticleDevelopment (Cambridge, England)2022

UHRF2 regulates cell cycle, epigenetics and gene expression to control the timing of retinal progenitor and ganglion cell differentiation.

Xiaohong Wang, Aaron L Sarver, Qiyuan Han, Christopher L Seiler, Chencheng Xie, Huarui Lu, Colleen L Forster, Natalia Y Tretyakova, Timothy C Hallstrom

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. UHRF2 accumulates in early GCell cycle (Georgetown, Tex.) · 2024
    Article
  6. E3 Ubiquitin LigaseInternational journal of molecular sciences · 2024
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Xiaohong WangDepartment of Pediatrics, Division of Blood and Marrow Transplantation, 420 Delaware Street S.E., University of Minnesota, Minneapolis, MN 55455, USA.
Aaron L SarverInstitute for Health Informatics, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA.
Qiyuan HanDepartment of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Christopher L SeilerDepartment of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Chencheng XieDepartment of Pediatrics, Division of Blood and Marrow Transplantation, 420 Delaware Street S.E., University of Minnesota, Minneapolis, MN 55455, USA.
Huarui LuDepartment of Pediatrics, Division of Blood and Marrow Transplantation, 420 Delaware Street S.E., University of Minnesota, Minneapolis, MN 55455, USA.
Colleen L ForsterBioNet, Academic Health Center, University of Minnesota, Minneapolis, MN 55455, USA.
Natalia Y TretyakovaDepartment of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Timothy C HallstromDepartment of Pediatrics, Division of Blood and Marrow Transplantation, 420 Delaware Street S.E., University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-5677-3032
University of Minnesota · US

Funding

Smoking-Induced Epigenetic Changes in the Lung: Role of DNA DemethylationR01CA095039 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TRETYAKOVA, NATALIA Y · 2003 to 2022
$3.6M
Cell Fate Control by Integrated E2F, FoxO and PI3K Signaling in RetinoblastomaR01CA168622 · NCI · UNIVERSITY OF MINNESOTA · PI HALLSTROM, TIMOTHY C. · 2013 to 2017
$1.6M
NCI NIH HHS R01 CA095039NCI NIH HHS R01 CA168622
6 · The paper itself

Abstract

Ubiquitin-like, containing PHD and RING finger domains 2 (UHRF2) regulates cell cycle and binds 5-hydroxymethylcytosine (5hmC) to promote completion of DNA demethylation. Uhrf2-/- mice are without gross phenotypic defects; however, the cell cycle and epigenetic regulatory functions of Uhrf2 during retinal tissue development are unclear. Retinal progenitor cells (RPCs) produce all retinal neurons and Müller glia in a predictable sequence controlled by the complex interplay between extrinsic signaling, cell cycle, epigenetic changes and cell-specific transcription factor activation. In this study, we find that UHRF2 accumulates in RPCs, and its conditional deletion from mouse RPCs reduced 5hmC, altered gene expressions and disrupted retinal cell proliferation and differentiation. Retinal ganglion cells were overproduced in Uhrf2-deficient retinae at the expense of VSX2+ RPCs. Most other cell types were transiently delayed in differentiation. Expression of each member of the Tet3/Uhrf2/Tdg active demethylation pathway was reduced in Uhrf2-deficient retinae, consistent with locally reduced 5hmC in their gene bodies. This study highlights a novel role of UHRF2 in controlling the transition from RPCs to differentiated cell by regulating cell cycle, epigenetic and gene expression decisions.

Indexed as

Epigenesis, GeneticRetinaAnimalsCell CycleCell DifferentiationGene ExpressionHomeodomain ProteinsMiceRetinal Ganglion CellsTranscription FactorsUbiquitin-Protein LigasesHomeodomain ProteinsTranscription FactorsUbiquitin-Protein LigasesUHRF2 protein, mouseVsx2 protein, mouse5hmC5-hydroxymethylcytosinemouseRetinaTETUHRF2

Identifiers

PMID35285483
PMCPMC8984156
OpenAlexW4220812095

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.