Evidence map›Paper›PMID 35285681›Full record

ArticleJournal of virology2022

Mouse Adenovirus Type 1 E4orf6 Induces PKR Degradation.

Berto Tejera-Hernández, Danielle E Goodman, Juan M Nevarez, Katherine R Spindler

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 3 citations in OpenAlex.

  1. Infection and immunity · 2026
    Article
  2. bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Berto Tejera-HernándezDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-5418-4955
Danielle E GoodmanDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Juan M NevarezDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-8613-7512
Katherine R SpindlerDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-9829-6051
University of Michigan · US

Funding

Viral interaction with host eIF2alpha kinasesR01AI133935 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPINDLER, KATHERINE R. · 2018 to 2022
$3.0M
NIAID NIH HHS R01 AI133935
6 · The paper itself

Abstract

Protein kinase R (PKR) is a cellular kinase involved in the antiviral response. The inactivation or inhibition of this protein is a conserved activity in DNA and RNA virus infections. In contrast to human adenovirus type 5, mouse adenovirus type 1 (MAV-1) inhibits PKR activity through proteasome-dependent degradation. However, the molecular mechanism by which this process takes place is not fully understood. We investigated whether ubiquitination, MAV-1 early region 1B 55k (E1B 55k), and early region 4 orf6 (E4orf6) play a role in PKR degradation in MAV-1 infection, because the enzyme 3 (E3) ubiquitin ligase activity with these viral proteins is conserved among the

Indexed as

AdenoviridaeAdenoviridae InfectionseIF-2 KinaseProteolysisAdenovirus E1B ProteinsAdenovirus E4 ProteinsAdenoviruses, HumanAnimalsHumansMiceProteasome Endopeptidase ComplexViral ProteinsAdenovirus E1B ProteinsAdenovirus E4 ProteinseIF-2 KinaseProteasome Endopeptidase ComplexViral Proteinscullinmouse adenovirusPKRproteasomeubiquitination

Identifiers

PMID35285681
PMCPMC9006929
OpenAlexW4220729456

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.