ArticleNutrition & diabetes2022
Cognitive glucose sensitivity-proposing a link between cognitive performance and reliance on external glucose uptake.
Article in Nutrition & diabetes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 2 citations in OpenAlex.
- Activation of the AMPK Signaling and Brain Function: A Friend or Foe?Journal of neurochemistry · 2025Review
- [Self-reported cognitive glucose sensitivity: association with long-term blood-glucose-levels and diabetes-related distress in individuals with type 1 diabetes].Pravention und Gesundheitsforderung · 2023Article
- Spirometry has added value over electrodermal activity as a physiological marker of mental load in male subjects.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Existing evidence on the effects of glucose supplementation on cognitive performance appears inconclusive. Metabolic switching offers an approach to explain such incoherent findings based on differences in cognitive functioning after fasting. We propose a new construct, cognitive glucose sensitivity (CGS), which quantifies individual performance gain due to glucose supplementation. We tested the hypothesis that the effects of glucose ingestion depend on CGS, cognitive task domain, and sex. In addition, the relationship between CGS and body mass index (BMI) was examined. Seventy-one participants (48 female) were tested in two conditions each (deprivation baseline vs. glucose supplementation), performing tasks from different cognitive domains (memory and executive functioning). We found significant evidence for a correlation of deprivation baseline performance and CGS across domains (Corsi-Block-Tapping Task: r = -0.57, p < 0.001; Go-No-Go Task: r = 0.39, p = 0.001; word list recall: r = -0.50, p < 0.001). Moreover, individual CGS differed significantly between tasks (p = 0.018). Only in men, BMI was significantly related to CGS in a word recall paradigm (r = 0.49, p = 0.017). Our findings support the notion that the effects of glucose depend on CGS, task domain, and sex. The effort to reduce performance impairment (short-term) might sacrifice independence from external glucose (long term), possibly via declining blood glucose regulation. Therefore, CGS could be regarded as a candidate to enhance our understanding of the etiology of unhealthy eating.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.