ArticleNature communications2022
Malfunction of airway basal stem cells plays a crucial role in pathophysiology of tracheobronchopathia osteoplastica.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Case report: anesthetic management for a partial nephrectomy in a patient with tracheobronchopathia osteoplastica.BMC pulmonary medicine · 2026Article
- Spatial Distribution of K13-Positive Airway Epithelial Cells in Idiopathic Pulmonary Fibrosis.Biomedicines · 2026Article
- A serum-free culture medium for long-term expansion of human airway basal stem cells.Stem cell research & therapy · 2026Article
- First Whole-Genome Sequencing Analysis of Tracheobronchopathia Osteochondroplastica with Critical Vocal Cord Involvement: Proposing a Novel Pathophysiological Model.Diagnostics (Basel, Switzerland) · 2026Article
- Classic Bronchoscopic Nodularity Sparing the Posterior Wall: A Case of Tracheobronchopathia Osteochondroplastica.Cureus · 2025Article
- Article
- KRT5Stem cell research & therapy · 2025Article
- Ferrostatin-1 inhibits tracheal basal cell ferroptosis to facilitate the rapid epithelization of 3D-printed tissue-engineered tracheas.Stem cell research & therapy · 2025Article
- Tracheobronchial ossification in children: a case report and review of the literature.Frontiers in pediatrics · 2025Article
- Mechanisms of Bone Morphogenetic Protein 2 in Respiratory Diseases.Current allergy and asthma reports · 2024Review
- Connexin 25 maintains self-renewal and functions of airway basal cells for airway regeneration.Stem cell research & therapy · 2024Article
- Airway disease decreases the therapeutic potential of epithelial stem cells.Respiratory research · 2024Article
- Human apical-out nasal organoids reveal an essential role of matrix metalloproteinases in airway epithelial differentiation.Nature communications · 2024Article
- Tracheobronchopathia osteochondroplastica: clinical, bronchoscopic, and comorbid features in a case series.BMC pulmonary medicine · 2022Article
- Building and validating an artificial intelligence model to identify tracheobronchopathia osteochondroplastica by using bronchoscopic images.Therapeutic advances in respiratory diseaseArticle
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding disease-associated stem cell abnormality has major clinical implications for prevention and treatment of human disorders, as well as for regenerative medicine. Here we report a multifaceted study on airway epithelial stem cells in Tracheobronchopathia Osteochondroplastica (TO), an under-detected tracheobronchial disorder of unknown etiology and lack of specific treatment. Epithelial squamous metaplasia and heterotopic bone formation with abnormal cartilage proliferation and calcium deposits are key pathological hallmarks of this disorder, but it is unknown whether they are coincident or share certain pathogenic mechanisms in common. By functional evaluation and genome-wide profiling at both transcriptional and epigenetic levels, we reveal a role of airway basal cells in TO progression by acting as a repository of inflammatory and TGFβ-BMP signals, which contributes to both epithelial metaplasia and mesenchymal osteo-chondrogenesis via extracellular signaling and matrix remodeling. Restoration of microenvironment by cell correction or local pathway intervention may provide therapeutic benefits.
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