ReviewAdvances in experimental medicine and biology2022
Phosphate and Endothelial Function: How Sensing of Elevated Inorganic Phosphate Concentration Generates Signals in Endothelial Cells.
Review in Advances in experimental medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
- BACE2-Induced Aberrant Lymphatic Network Aggravates the Local Inflammation in Arteriovenous Fistulas With Hyperphosphatemia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Present in all cells, inorganic phosphate (Pi) is involved in regulating a wide range of fundamental cellular processes including energy homeostasis; nucleotide, nucleic acid and phospholipid metabolism; and signalling through protein phosphorylation events. However, at excess concentrations, Pi is known to exert adverse effects on cells, particularly on endothelial cells. This review gives a brief overview of the functional effects of elevated extracellular Pi concentration on mammalian cells and tissues in vitro and in vivo. We then address the cardiovascular effects of elevated extracellular Pi concentration in vitro and in vivo, emphasising that effects have been reported in vivo even within the top end of normal range for plasma [Pi]. Cardiovascular sites of action of Pi are then considered, with a focus on the role of soluble Pi in endothelial dysfunction. The regulation of intracellular Pi concentration by Pi transporter proteins in mammalian cells is described, followed by consideration in detail of how changes in Pi concentration are sensed in mammalian cells and how these trigger functional effects in endothelial cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.