ArticleThe New phytologist2022
Kiwifruit MYBS1-like and GBF3 transcription factors influence l-ascorbic acid biosynthesis by activating transcription of GDP-L-galactose phosphorylase 3.
Article in The New phytologist, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 100 citations in OpenAlex.
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- A Hierarchical VvbHLH30-VvERF70-VvACS2 Module Orchestrates Ethylene Biosynthesis and Cold Adaptation in Grapevine.Plant biotechnology journal · 2026Article
- Allelic structural variation at the NLR25-1 locus enhances defense against Pseudomonas syringae in kiwifruit.Genome biology · 2026Article
- Haplotype-resolved t2t genome of paliurus hemsleyanus provides insights into rhamnaceae evolution and genome biology.Communications biology · 2025Article
- Aquilaria sinensis MYB-Like Transcription Factor AsMYB1 Promotes 2-(2-Phenylethyl)Chromone Biosynthesis Through Interacting With 14-3-3 Family Protein AsGRF1.Plant biotechnology journal · 2025Article
- Molecular Breeding for Abiotic Stress Tolerance in Crops: Recent Developments and Future Prospectives.International journal of molecular sciences · 2025Review
- Molecular mechanisms of high levels of L-ascorbic acid accumulation in chestnut rose fruits.Plant communications · 2025Article
- MsAREB1 enhances combined cold and saline-alkali stress tolerance by promoting ascorbic acid biosynthesis in alfalfa.Plant biotechnology journal · 2025Article
- AcABI5a integrates abscisic acid signaling to developmentally modulate fruit ascorbic acid biosynthesis in kiwifruit.Horticulture research · 2025Article
- Tissue- and Condition-Specific Biosynthesis of Ascorbic Acid inInternational journal of molecular sciences · 2025Article
- Chromosome-level genome assembly assisting for dissecting mechanism of anthocyanin regulation in kiwifruit (Actinidia arguta).Molecular horticulture · 2025Article
- The regulatory module MdCPCL-MdILR3L mediates the synthesis of ascorbic acid and anthocyanin in apple.Plant biotechnology journal · 2025Article
- A bHLH transcription factor RrUNE12 regulates salt tolerance and promotes ascorbate synthesis.Plant cell reports · 2025Article
- Super pan-genome reveals extensive genomic variations associated with phenotypic divergence in Actinidia.Molecular horticulture · 2025Article
- A Model for Selecting Kiwifruit (Foods (Basel, Switzerland) · 2024Article
- Divergence in MiRNA targeting of AchAco and its role in citrate accumulation in kiwifruit.BMC plant biology · 2024Article
- Genomes of diverse Actinidia species provide insights into cis-regulatory motifs and genes associated with critical traits.BMC biology · 2024Article
- Genetic Analysis of Vitamin C Content in Rapeseed Seedlings by the Major Gene Plus Polygene Mixed Effect Model.Current issues in molecular biology · 2024Article
- Profiling the Bioactive Compounds in Broccoli Heads with Varying Organ Sizes and Growing Seasons.Plants (Basel, Switzerland) · 2024Article
Corrections and comments
- Erratum issuedCorrigendum.2022
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant-derived Vitamin C (l-ascorbic acid (AsA)) is crucial for human health and wellbeing and thus increasing AsA content is of interest to plant breeders. In plants GDP-l-galactose phosphorylase (GGP) is a key biosynthetic control step and here evidence is presented for two new transcriptional activators of GGP. AsA measurement, transcriptomics, transient expression, hormone application, gene editing, yeast 1/2-hybrid, and electromobility shift assay (EMSA) methods were used to identify two positively regulating transcription factors. AceGGP3 was identified as the most highly expressed GGP in Actinidia eriantha fruit, which has high fruit AsA. A gene encoding a 1R-subtype myeloblastosis (MYB) protein, AceMYBS1, was found to bind the AceGGP3 promoter and activate its expression. Overexpression and gene-editing show AceMYBS1 effectively increases AsA accumulation. The bZIP transcription factor AceGBF3 (a G-box binding factor), also was shown to increase AsA content, and was confirmed to interact with AceMYBS1. Co-expression experiments showed that AceMYBS1 and AceGBF3 additively promoted AceGGP3 expression. Furthermore, AceMYBS1, but not GBF3, was repressed by abscisic acid, resulting in reduced AceGGP3 expression and accumulation of AsA. This study sheds new light on the roles of MYBS1 homologues and ABA in modulating AsA synthesis, and adds to the understanding of mechanisms underlying AsA accumulation.
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