Evidence map›Paper›PMID 35289633›Full record

ArticleInfection and immunity2022

Pseudomonas Synergizes with Fluconazole against

Siham Hattab, Anna-Maria Dagher, Robert T Wheeler

Open access · hybridAbstract read
In one paragraph

Article in Infection and immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Interactions betweenInfection and immunity · 2026
    Article
  3. Article
  4. Review
  5. Evaluation of the antagonistic effect ofIranian journal of microbiology · 2025
    Article
  6. microPublication biology · 2025
    Article
  7. The pathobiology of human fungal infections.Nature reviews. Microbiology · 2024
    Review
  8. Review
  9. Candida-bacterial cross-kingdom interactions.Trends in microbiology · 2023
    Review
  10. Article
  11. Rapid Synergistic Biofilm Production ofInternational journal of molecular sciences · 2022
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Siham HattabDepartment of Molecular & Biomedical Sciences, University of Mainegrid.21106.34, Orono, Maine, USA.
Anna-Maria DagherDepartment of Molecular & Biomedical Sciences, University of Mainegrid.21106.34, Orono, Maine, USA.
Robert T WheelerDepartment of Molecular & Biomedical Sciences, University of Mainegrid.21106.34, Orono, Maine, USA.ORCID 0000-0003-3223-7021
University of Maine · US

Funding

Genetic determinants of bacterial-drug synergy against CandidaR15AI169393 · NIAID · UNIVERSITY OF MAINE ORONO · PI WHEELER, ROBERT T. · 2023 to 2023
$435k
Genetics and visualization of innate host response to C. albicans infection in viR15AI094406 · NIAID · UNIVERSITY OF MAINE ORONO · PI WHEELER, ROBERT T. · 2012 to 2012
$422k
Intravital study of innate immunity to mucosal candidiasisR15AI133415 · NIAID · UNIVERSITY OF MAINE ORONO · PI WHEELER, ROBERT T. · 2018 to 2018
$415k
NIAID NIH HHS R15 AI094406NIAID NIH HHS R15 AI133415NIAID NIH HHS R15 AI169393U.S. Department of Agriculture (USDA) ME0-21821
6 · The paper itself

Abstract

Polymicrobial infections are challenging to treat because we don't fully understand how pathogens interact during infection and how these interactions affect drug efficacy. Candida albicans and Pseudomonas aeruginosa are opportunistic pathogens that can be found in similar sites of infection such as in burn wounds and most importantly in the lungs of CF and mechanically ventilated patients. C. albicans is particularly difficult to treat because of the paucity of antifungal agents, some of which lack fungicidal activity. In this study, we investigated the efficacy of anti-fungal treatment during C. albicans-P. aeruginosa coculture

Indexed as

CoinfectionFluconazoleAnimalsAntifungal AgentsCandidaCandida albicansDrug Resistance, FungalHumansIronMicrobial Sensitivity TestsPseudomonasPseudomonas aeruginosaZebrafishAntifungal AgentsFluconazoleIronCandidafluconazolemucosalpolymicrobialPseudomonas aeruginosazebrafish

Identifiers

PMID35289633
PMCPMC9022521
OpenAlexW4220719204

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.