ArticleHuman brain mapping2022
Structural and functional biomarkers of the insula subregions predict sex differences in aggression subscales.
Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 7 citations in OpenAlex.
- The architecture of depression and comorbid symptoms in chinese vocational college students: a dual-method network analysis.Social psychiatry and psychiatric epidemiology · 2026Article
- Real-time aggression in youth and its connection to region-specific structural brain alterations.Discover mental health · 2025Article
- The Effect of Modular Degeneracy on Neuroimaging Data.Brain connectivity · 2025Article
- Trauma, resilience and significant relationships: Sex differences in protective factors for military mental health.The Australian and New Zealand journal of psychiatry · 2025Article
- Neuroanatomical and neurocognitive correlates of delusion in Alzheimer's disease and mild cognitive impairment.BMC neurology · 2024Article
- Structural and functional biomarkers of the insula subregions predict sex differences in aggression subscales.Human brain mapping · 2022Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aggression is a common and complex social behavior that is associated with violence and mental diseases. Although sex differences were observed in aggression, the neural mechanism for the effect of sex on aggression behaviors remains unclear, especially in specific subscales of aggression. In this study, we investigated the effects of sex on aggression subscales, gray matter volume (GMV), and functional connectivity (FC) of each insula subregion as well as the correlation of aggression subscales with GMV and FC. This study found that sex significantly influenced (a) physical aggression, anger, and hostility; (b) the GMV of all insula subregions; and (c) the FC of the dorsal agranular insula (dIa), dorsal dysgranular insula (dId), and ventral dysgranular and granular insula (vId_vIg). Additionally, mediation analysis revealed that the GMV of bilateral dIa mediates the association between sex and physical aggression, and left dId-left medial orbital superior frontal gyrus FC mediates the relationship between sex and anger. These findings revealed the neural mechanism underlying the sex differences in aggression subscales and the important role of the insula in aggression differences between males and females. This finding could potentially explain sexual dimorphism in neuropsychiatric disorders and improve dysregulated aggressive behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.