ArticleCirculation. Cardiovascular imaging2022
Breast Arterial Calcification: a Novel Cardiovascular Risk Enhancer Among Postmenopausal Women.
Article in Circulation. Cardiovascular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06865885 (Study of Optimal LDL-C Value Enhancement With Inclisiran in Patients With Multiple Comorbidities in Which There Are Drug-Drug Interactions Limiting LDL-C Lowering), which is not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of Optimal LDL-C Value Enhancement With Inclisiran in Patients With Multiple Comorbidities in Which There Are Drug-Drug Interactions Limiting LDL-C Lowering
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Breast arterial calcifications on mammography and risk of stroke: a systematic review and meta-analysis.Frontiers in neurology · 2026Pooled it
- Review
- A novel deep learning-based grading system for assessing breast arterial calcification on mammograms, as an independent risk factor for predicting adverse cardiovascular events.La Radiologia medica · 2026Article
- Cardiovascular disease in women: traditional and sex-specific risk factors.European heart journal · 2026Review
- Breast Artery Calcification for Primary Prevention of Major Adverse Cardiovascular Outcomes in Women.JACC. Advances · 2026Article
- Review of breast arterial calcifications for cardiovascular disease risk prediction.NPJ cardiovascular health · 2026Review
- Beyond the Coronaries: Utility of Extra-Coronary Calcification for Cardiovascular Risk Assessment in Women.Current atherosclerosis reports · 2026Review
- Artificial intelligence-based quantification of breast arterial calcifications to predict cardiovascular morbidity and mortality.European heart journal · 2026Article
- AI-Quantified Breast Arterial Calcification Can Predict Heart Disease Risk From Mammograms.Journal of medical Internet research · 2026Article
- Artificial Intelligence for Cardiovascular Care in Action: From Learning to Implementation in Health Systems.JACC. Advances · 2025Review
- State-of-the-art wearable sensors for cardiovascular health: a review.NPJ cardiovascular health · 2025Review
- Review
- Relationship between the prevalence of breast arterial calcifications on mammography and coronary calcifications on Chest CT: A cross-sectional study.Saudi medical journal · 2025Article
- Transforming Population Health Screening for Atherosclerotic Cardiovascular Disease with AI-Enhanced ECG Analytics: Opportunities and Challenges.Current atherosclerosis reports · 2025Review
- Incidental Finding of Coronary and Non-Coronary Artery Calcium: What Do Clinicians Need To Know?Current atherosclerosis reports · 2025Review
- The Impact of Artificial Intelligence on Women's Cardiovascular Disease Care.Current cardiology reports · 2025Review
- Breast Arterial Calcifications on Mammography: A Review of the Literature.Journal of breast imaging · 2025Review
- The Lancet Commission on rethinking coronary artery disease: moving from ischaemia to atheroma.Lancet (London, England) · 2025Review
- Association of Mammographic Features and Major Adverse Cardiac Events in Postmenopausal Women: A 10-Year Retrospective Cohort Study.International journal of women's health · 2025Article
- Breast Arterial Calcification on a Screening Mammogram: A Potential Cardiovascular Risk Stratification Tool in Women.Reviews in cardiovascular medicine · 2025Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundBreast arterial calcification (BAC), a common incidental finding in mammography, has been shown to be associated with angiographic coronary artery disease and cardiovascular disease (CVD) outcomes. We aimed to (1) examine the association of BAC presence and quantity with hard atherosclerotic CVD (ASCVD) and global CVD; (2) ascertain model calibration, discrimination and reclassification of ASCVD risk; (3) assess the joint effect of BAC presence and 10-year pooled cohorts equations risk on ASCVD.
methodsA cohort study of 5059 women aged 60-79 years recruited after attending mammography screening between October 2012 and February 2015 was conducted in a large health plan in Northern California, United States. BAC status (presence versus absence) and quantity (calcium mass mg) was determined using digital mammograms. Prespecified end points were incident hard ASCVD and a composite of global CVD.
resultsTwenty-six percent of women had BAC >0 mg. After a mean (SD) follow-up of 6.5 (1.6) years, we ascertained 155 (3.0%) ASCVD events and 427 (8.4%) global CVD events. In Cox regression adjusted for traditional CVD risk factors, BAC presence was associated with a 1.51 (95% CI, 1.08-2.11;
conclusionsOur results indicate that BAC has potential utility for primary CVD prevention and, therefore, support the notion that BAC ought to be considered a risk-enhancing factor for ASCVD among postmenopausal women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.