Evidence map›Paper›PMID 35290169›Full record

Trial reportAmerican journal of respiratory and critical care medicine2022

Anti-Granulocyte-Macrophage Colony-Stimulating Factor Monoclonal Antibody Gimsilumab for COVID-19 Pneumonia: A Randomized, Double-Blind, Placebo-controlled Trial.

Gerard J Criner, Frederick M Lang, Robert L Gottlieb, Kusum S Mathews, Tisha S Wang, Todd W Rice, Deepu Madduri, Shashi Bellam, Robert Jeanfreau, Amy H Case and 13 more

Erratum issuedOpen access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Adverse drug reactions associated with COVID-19 management.Naunyn-Schmiedeberg's archives of pharmacology · 2024
    Review
  8. COVID-19 Pneumonia and Cytokine Storm Syndrome.Advances in experimental medicine and biology · 2024
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. The role of lung macrophages in acute respiratory distress syndrome.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022
    Review
  14. Review
  15. Article
  16. Review
  17. Less Haste, More Speed, More Science: Lessons to be Learned from COVID-19 Studies.American journal of respiratory and critical care medicine · 2022
    Article
  18. Immunomodulatory therapies for COVID-19.Frontiers in medicine · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors at 19 institutions in 1 country.

Gerard J CrinerDepartment of Thoracic Medicine and Surgery, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania.
Frederick M LangRoivant Sciences, New York, New York.ORCID 0000-0001-8866-4490
Robert L GottliebBaylor University Medical Center, Dallas, Texas.ORCID 0000-0001-8376-8709
Kusum S MathewsIcahn School of Medicine at Mount Sinai, New York, New York.
Tisha S WangUniversity of California Los Angeles David Geffen School of Medicine, Los Angeles, California.
Todd W RiceVanderbilt University Medical Center, Nashville, Tennessee.
Deepu MadduriIcahn School of Medicine at Mount Sinai, New York, New York.
Shashi BellamNorthShore University HealthSystem, Evanston, Illinois.
Robert JeanfreauEast Jefferson General Hospital, Metaire, Lousiana.
Amy H CasePiedmont Healthcare, Atlanta, Georgia.
Marilyn K GlassbergUniversity of Arizona College of Medicine/Banner University Medical Center, Phoenix, Arizona.
George Marshall LyonEmory University School of Medicine, Atlanta, Georgia.
Kareem AhmadInova Fairfax Hospital, Falls Church, Virginia.
Robert MendelsonJamaica Hospital Medical Center, Jamaica, New York.
J Michael DiMaioBaylor Scott & White The Heart Hospital-Plano, Plano, Texas.
MaryAnn P TranBaylor Scott & White Medical Center-Round Rock, Round Rock, Texas.
Cedric W SpakBaylor University Medical Center, Dallas, Texas.
Jamil A AbbasiBaylor Scott & White All Saints Medical Center, Fort Worth, Texas.
Steven G DavisBaylor Scott & White Medical Center-Irving, Irving, Texas.
Shekhar GhamandeBaylor Scott & White Medical Center-Temple, Temple, Texas; and.
Steven ShenRoivant Sciences, New York, New York.
Lisa ShermanRoivant Sciences, New York, New York.
Simon LowryRoivant Sciences, New York, New York.
Roivant Sciences (United States) · USBaylor University Medical Center · USIcahn School of Medicine at Mount Sinai · USBanner - University Medical Center Phoenix · USBaylor Scott & White All Saints Medical Center · USBaylor Scott & White Health · USBaylor Scott & White Medical Center - Temple · USEast Jefferson General Hospital · USEmory University · USHeart Hospital Baylor Plano · USInova Fairfax Hospital · USJamaica Hospital · USNorthShore University HealthSystem · USPiedmont HealthCare · USSt. David's Round Rock Medical Center · USTemple University · USTheravance Biopharma (United States) · USUniversity of California, Los Angeles · USVanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

COVID-19 Drug TreatmentAntibodies, Monoclonal, HumanizedDouble-Blind MethodHumansInflammationAntibodies, Monoclonal, Humanizedgimsilumabacute respiratory distress syndromeCOVID-19gimsilumabGM-CSFSARS-CoV-2

Identifiers

PMID35290169
PMCPMC9873114
OpenAlexW4220915751

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.