Evidence map›Paper›PMID 35290489›Full record

ArticlePediatric radiology2022

Dynamic susceptibility-contrast magnetic resonance imaging with contrast agent leakage correction aids in predicting grade in pediatric brain tumours: a multicenter study.

Stephanie B Withey, Lesley MacPherson, Adam Oates, Stephen Powell, Jan Novak, Laurence Abernethy, Barry Pizer, Richard Grundy, Paul S Morgan, Simon Bailey and 5 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 10 institutions in 1 country.

Stephanie B WitheyRRPPS, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Lesley MacPhersonRadiology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
Adam OatesRadiology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
Stephen PowellInstitute of Cancer and Genomic Sciences, University of Birmingham, Birmingham, UK.
Jan NovakOncology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
Laurence AbernethyRadiology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
Barry PizerOncology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
Richard GrundyThe Children's Brain Tumour Research Centre, University of Nottingham, Nottingham, UK.
Paul S MorganThe Children's Brain Tumour Research Centre, University of Nottingham, Nottingham, UK.
Simon BaileySir James Spence Institute of Child Health, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Dipayan MitraNeuroradiology, Royal Victoria Infirmary, Newcastle upon Tyne, UK.
Theodoros N ArvanitisOncology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
Dorothee P AuerDivision of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, UK.
Shivaram AvulaRadiology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
Andrew C PeetOncology, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK. a.peet@bham.ac.uk.ORCID 0000-0002-4846-5152
Alder Hey Children's NHS Foundation Trust · GBBirmingham Women’s and Children’s NHS Foundation Trust · GBNottingham University Hospitals NHS Trust · GBRoyal Victoria Infirmary · GBAston University · GBBirmingham Children's Hospital · GBUniversity Hospitals Birmingham NHS Foundation Trust · GBUniversity of Birmingham · GBUniversity of Nottingham · GBUniversity of Warwick · GB

Funding

Cancer Research UK C7809/A10342Cancer Research UK C8232/A25261Department of Health NIHR-RP-R2-12-019
6 · The paper itself

Abstract

backgroundRelative cerebral blood volume (rCBV) measured using dynamic susceptibility-contrast MRI can differentiate between low- and high-grade pediatric brain tumors. Multicenter studies are required for translation into clinical practice.

objectiveWe compared leakage-corrected dynamic susceptibility-contrast MRI perfusion parameters acquired at multiple centers in low- and high-grade pediatric brain tumors. MATERIALS AND

methodsEighty-five pediatric patients underwent pre-treatment dynamic susceptibility-contrast MRI scans at four centers. MRI protocols were variable. We analyzed data using the Boxerman leakage-correction method producing pixel-by-pixel estimates of leakage-uncorrected (rCBV

resultsForty tumors were classified as low grade, 45 as high grade. Mean whole-tumor median rCBV

conclusionDynamic susceptibility-contrast MRI acquired at multiple centers helped distinguish between children's brain tumors. Relative cerebral blood volume was significantly higher in high-grade compared to low-grade tumors and differed among common tumor types. Vessel leakage correction is required to provide accurate rCBV, particularly in low-grade enhancing tumors.

Indexed as

AstrocytomaBrain NeoplasmsCerebral Blood VolumeChildContrast MediaHumansMagnetic Resonance ImagingContrast MediaBlood volumeBrainChildrenDynamic susceptibility-contrast magnetic resonance imagingLeakage correctionMagnetic resonance imagingMulticenterPerfusionTumor

Identifiers

PMID35290489
PMCPMC9107460
OpenAlexW4221092634

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.