ReviewOrphanet journal of rare diseases2022
Legg-Calvé-Perthes disease overview.
Review in Orphanet journal of rare diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- The MTHFR C677T polymorphism and protection against Legg-Calvé-Perthes disease in children: an updated systematic review and meta-analysis.Orphanet journal of rare diseases · 2026Pooled it
- Role of Non-Coding RNAs in Pathogenesis, Diagnosis, and Therapy of Legg-Calvé-Perthes Disease: A Systematic Review.Medical science monitor : international medical journal of experimental and clinical research · 2025Pooled it
- Nationwide Epidemiological and Demographic Evolution of Legg-Calvé-Perthes Disease: A 10-Year Analysis.Journal of the Pediatric Orthopaedic Society of North America · 2026Article
- Diagnostic Yield of Genetic Disorders in Children with Hip Dysplasia Mimicking Bilateral Legg-Calvé-Perthes Disease.Diagnostics (Basel, Switzerland) · 2026Article
- Article
- Article
- Familial Cases of Legg-Calvé-Perthes Disease-Hemostatic and Molecular Markers.International journal of molecular sciences · 2026Article
- Treatment for primary avascular necrosis of the lower limb in childhood.The Cochrane database of systematic reviews · 2026Article
- Article
- Exploring the alteration of gut microbiota in the rats with steroid-induce osteonecrosis of the femoral head.BMC microbiology · 2025Article
- Metabolic glycoengineered exosome-A2M nanoplatform reprograms macrophage polarization and orchestrates bone regeneration in ONFH.Cell death discovery · 2025Article
- Femoral head vascular status in early-stage Legg-Calvé-Perthes disease assessed by contrast-enhanced magnetic resonance imaging: comparison with the contralateral side.Orphanet journal of rare diseases · 2025Article
- Risk factors associated with greater trochanteric overgrowth secondary to Legg-Calvé-Perthes disease: a retrospective observational study.BMC pediatrics · 2025Observational
- Association ofGenes · 2025Article
- Secreted Frizzled-Related Protein 2 Promotes Osteogenic Differentiation and Bone Regeneration in Perthes Disease When Targeted by miR-106a-5p.Journal of cellular and molecular medicine · 2025Article
- The multifaceted roles of extracellular vesicles in osteonecrosis of the femoral head.Journal of orthopaedic translation · 2025Review
- The Availability and Readability of Multilingual Online Patient Materials for Legg-Calve-Perthes Disease.Journal of the Pediatric Orthopaedic Society of North America · 2025Article
- The application of Large Language Models to the phenotype-based prioritization of causative genes in rare disease patients.Scientific reports · 2025Article
- Conservative Management of Late-Onset Legg-Calvé-Perthes Disease in a 10-Year-Old Child: A Case Report.JNMA; journal of the Nepal Medical Association · 2025Article
- Incidence and complication rate of arthroplasty in Perthes disease management: A systematic review and meta-analysis.Journal of Taibah University Medical Sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLegg-Calvé-Perthes Disease (LCPD) is a necrosis of the femoral head which affects the range of motion of the hips. Its incidence is variable, ranging from 0.4/100,000 to 29.0/ 100,000 children. Although LCPD was first described in the beginning of the past century, limited is known about its etiology. Our objective is to describe the main areas of interest in Legg-Calve-Perthes disease.
methodsA review of the literature regarding LCPD etiology was performed, considering the following inclusion criteria: Studies reporting clinical or preclinical results. The research group carried out a filtered search on the PubMed and Science Direct databases. To maximize the suitability of the search results, we combined the terms ''Perthes disease" OR "LCPD" OR "children avascular femoral head necrosis" with "diagnostic" OR "treatment" OR "etiology" as either key words or MeSH terms.
resultsIn this article been described some areas of interest in LCPD, we include topics such as: history, incidence, pathogenesis, diagnosis, treatment and possible etiology, since LCPD has an unknown etiology.
conclusionsThis review suggests that LCPD has a multifactorial etiology where environmental, metabolic and genetic agents could be involved.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.