ArticleScience advances2022
Mechanically reinforced biotubes for arterial replacement and arteriovenous grafting inspired by architectural engineering.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed.
- A Muscle-Mimetic Core-Sheath Composite Yarn Scaffold for In-Body Tissue Induction and Regeneration of Small-Diameter Vascular Grafts.Advanced healthcare materials · 2026Article
- Phosphatidylserine-everted erythrocyte membrane vesicles enhance efferocytosis and remodeling of vascular grafts.Nature communications · 2026Article
- Reinforced biotubes as readily available and regenerative vascular grafts.Nature communications · 2026Article
- Degradable scaffold-mediated synergistic matrix formation by endogenous cells: an in vivo manufacturing strategy for off-the-shelf vascular grafts to address clinical shortages.Journal of nanobiotechnology · 2026Article
- Programmable Compliance in Small-Diameter Vascular Grafts by Design of Melt-Electrowritten Scaffold Architectures for In Situ Tissue Engineering.Advanced healthcare materials · 2026Article
- Don't judge an implant by its cover: how the foreign body response and fibrotic capsule might be harnessed for good.npj biomedical innovations · 2026Review
- Rapid endothelialization of printed vascular grafts by perivascular niche-circulating endothelial progenitors crosstalk.Nature communications · 2025Article
- A bio-inspired screwed small-diameter vascular graft for endotheliazation and arterial regeneration.Bioactive materials · 2025Article
- Bioengineered cardiovascular bypass grafts via in vivo self-assembly of scaffold-guided tubular tissue in rats.Journal of nanobiotechnology · 2025Article
- Electronic vascular conduit for in situ identification of hemadostenosis and thrombosis in small animals and nonhuman primates.Nature communications · 2025Article
- Circumferentially Aligned Electrospun Vascular Grafts Improves Its Vascular Regeneration and Remodeling in vivo.International journal of nanomedicine · 2025Article
- Construction of vascular grafts based on tissue-engineered scaffolds.Materials today. Bio · 2024Review
- Review
- Stem-Cell-Based Small-Diameter Blood Vessels with 3D Printing.Small science · 2024Article
- Tailored endothelialization enabled by engineered endothelial cell vesicles accelerates remodeling of small-diameter vascular grafts.Bioactive materials · 2024Article
- Copper hydrogen phosphate nanosheets functionalized hydrogel with tissue adhesive, antibacterial, and angiogenic capabilities for tracheal mucosal regeneration.Journal of nanobiotechnology · 2024Article
- MimickingInnovation (Cambridge (Mass.)) · 2024Article
- Integrating coaxial electrospinning and 3D printing technologies for the development of biphasic porous scaffolds enabling spatiotemporal control in tumor ablation and osteochondral regeneration.Bioactive materials · 2024Article
- Adaptation process of decellularized vascular grafts as hemodialysis accessRegenerative biomaterials · 2024Article
- Enhancing cartilage regeneration and repair through bioactive and biomechanical modification of 3D acellular dermal matrix.Regenerative biomaterials · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is a lack in clinically-suitable vascular grafts. Biotubes, prepared using in vivo tissue engineering, show potential for vascular regeneration. However, their mechanical strength is typically poor. Inspired by architectural design of steel fiber reinforcement of concrete for tunnel construction, poly(ε-caprolactone) (PCL) fiber skeletons (PSs) were fabricated by melt-spinning and heat treatment. The PSs were subcutaneously embedded to induce the assembly of host cells and extracellular matrix to obtain PS-reinforced biotubes (PBs). Heat-treated medium-fiber-angle PB (hMPB) demonstrated superior performance when evaluated by in vitro mechanical testing and following implantation in rat abdominal artery replacement models. hMPBs were further evaluated in canine peripheral arterial replacement and sheep arteriovenous graft models. Overall, hMPB demonstrated appropriate mechanics, puncture resistance, rapid hemostasis, vascular regeneration, and long-term patency, without incidence of luminal expansion or intimal hyperplasia. These optimized hMPB properties show promise as an alternatives to autologous vessels in clinical applications.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.