ArticleCerebellum (London, England)2023
Real-life Wrist Movement Patterns Capture Motor Impairment in Individuals with Ataxia-Telangiectasia.
Article in Cerebellum (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- The Use of Digital Devices to Monitor Physical Behavior in Motor Neuron Disease: Systematic Review.Journal of medical Internet research · 2025Pooled it
- Movement Disorders and Smart Wrist Devices: A Comprehensive Study.Sensors (Basel, Switzerland) · 2025Pooled it
- Encouraging arm use in stroke survivors: the impact of smart reminders during a home-based intervention.Journal of neuroengineering and rehabilitation · 2024Trial
- Childhood-onset neurodegeneration and brain atrophy: definingJournal of medical genetics · 2026Article
- Contrastive Learning Model for Wearable-Based Ataxia Assessment.IEEE transactions on bio-medical engineering · 2026Article
- Advancing Wearable-Based Upper-Limb Stroke Recovery Assessment to the Clinic: A Comparison of Movement Segmentation Strategies.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Digital Outcomes of Upper Limb Ataxia Capture Meaningful Longitudinal Change and Treatment Response.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- At-home wearables and machine learning capture motor impairment and progression in adult ataxias.Brain : a journal of neurology · 2025Article
- Submovements Derived from Wearable Sensors Capture Ataxia Severity and Differ Across Motor Tasks and Directions of Motion.Cerebellum (London, England) · 2025Article
- Wearable sensors in paediatric neurology.Developmental medicine and child neurology · 2025Review
- Wrist accelerometry and machine learning sensitively capture disease progression in prodromal Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Biological kinematics: a detailed review of the velocity-curvature power law calculation.Experimental brain research · 2025Review
- Sensitive Quantification of Cerebellar Speech Abnormalities Using Deep Learning Models.IEEE access : practical innovations, open solutions · 2024Article
- Article
- Accelerometer-based measures in Friedreich ataxia: a longitudinal study on real-life activity.Frontiers in pharmacology · 2024Article
- Characterizing Movement Patterns of Older Individuals with T2D in Free-Living Environments Using Wearable Accelerometers.Journal of clinical medicine · 2023Article
- Estimation of ataxia severity in children with ataxia-telangiectasia using ankle-worn sensors.Journal of neurology · 2023Article
- At-home wearables and machine learning sensitively capture disease progression in amyotrophic lateral sclerosis.Nature communications · 2023Article
- Accuracy and Reliability of At-home Quantification of Motor Impairments Using a Computer-based Pointing Task with Children with Ataxia-Telangiectasia.ACM transactions on accessible computing · 2023Article
- Reliability and Discriminative Validity of Wearable Sensors for the Quantification of Upper Limb Movement Disorders in Individuals with Dyskinetic Cerebral Palsy.Sensors (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Sensitive motor outcome measures are needed to efficiently evaluate novel therapies for neurodegenerative diseases. Devices that can passively collect movement data in the home setting can provide continuous and ecologically valid measures of motor function. We tested the hypothesis that movement patterns extracted from continuous wrist accelerometer data capture motor impairment and disease progression in ataxia-telangiectasia. One week of continuous wrist accelerometer data were collected from 31 individuals with ataxia-telangiectasia and 27 controls aged 2-20 years old. Longitudinal wrist sensor data were collected in 14 ataxia-telangiectasia participants and 13 controls. A novel algorithm was developed to extract wrist submovements from the velocity time series. Wrist sensor features were compared with caregiver-reported motor function on the Caregiver Priorities and Child Health Index of Life with Disabilities survey and ataxia severity on the neurologist-performed Brief Ataxia Rating Scale. Submovements became smaller, slower, and less variable in ataxia-telangiectasia compared to controls. High-frequency oscillations in submovements were increased, and more variable and low-frequency oscillations were decreased and less variable in ataxia-telangiectasia. Wrist movement features correlated strongly with ataxia severity and caregiver-reported function, demonstrated high reliability, and showed significant progression over a 1-year interval. These results show that passive wrist sensor data produces interpretable and reliable measures that are sensitive to disease change, supporting their potential as ecologically valid motor biomarkers. The ability to obtain these measures from a low-cost sensor that is ubiquitous in smartwatches could help facilitate neurological care and participation in research regardless of geography and socioeconomic status.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.