Evidence map›Paper›PMID 35295960›Full record

ArticleBioMed research international2022

Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants.

Hong Mei, Baoming Yin, Wenhong Yang, Jingli Zhang, Hongyan Lu, Xiaobin Qi, Wenhua Mei, Hongzhong Zhang, Jianduan Zhang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Hong MeiDepartment of Maternal and Child Health Care, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, China.ORCID https://orcid.org/0000-0002-8266-7073
Baoming YinZhuhai Women and Children's Hospital, 543 Ningxi Road, Zhuhai, Guangdong, China.
Wenhong YangZhuhai People Hospital Affiliated to Jinan University, 79 Kangning Road, Zhuhai, Guangdong, China.
Jingli ZhangTraditional Chinese Medicine Hospital of Zhuhai in Guangdong Provice, 53 Jingle Road, Zhuhai, Guangdong, China.
Hongyan LuDepartment of Maternal and Child Health Care, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, China.
Xiaobin QiZhuhai Women and Children's Hospital, 543 Ningxi Road, Zhuhai, Guangdong, China.
Wenhua MeiPublic Hospital Administration of Zhuhai Municipality, 41 Jiaoyu Road, Zhuhai, Guangdong, China.
Hongzhong ZhangZhuhai Women and Children's Hospital, 543 Ningxi Road, Zhuhai, Guangdong, China.ORCID https://orcid.org/0000-0002-3100-1394
Jianduan ZhangDepartment of Maternal and Child Health Care, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, Hubei, China.ORCID https://orcid.org/0000-0002-7942-8362
Zhuhai People's Hospital · CNZhuhai Hospital of Integrated Traditional Chinese and Western Medicine · CNHuazhong University of Science and Technology · CNJinan University · CNWuhan Children's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Childhood overweight and obesity (OW/OB) is a worldwide public health problem, and its genetic risks remain unclear. Objectives: To investigate risks of OW/OB associated with genetic variances in Methods: We conducted a case-control study with 734 infants included at delivery and followed up to 12-month old. The classification and regression tree analysis were used to generate the structure of the gene-gene interactions, while the unconditional multivariate logistic regression models were applied to analyze the single SNP, gene-gene interactions, and cumulative effects of the genotypes on OW/OB, adjusted for potential confounders. Results: There were 219 (29.84%) OW/OB infants. Rs543874 G allele and rs11030104 AA genotype increased the risk of OW/OB in 12-month-old infants ( Conclusions: Rs543874, rs11030104, and rs11191580 were associated with OW/OB in 12-month-old Chinese infants, and the three SNPs together with rs10913469 and rs11165675 had a combined effect on OW/OB.

Indexed as

Epistasis, Genetic5'-NucleotidaseAllelesBrain-Derived Neurotrophic FactorCase-Control StudiesChinaDNA-Binding ProteinsFemaleGenotypeHumansInfantMaleNerve Tissue ProteinsObesityOverweightPolymorphism, Single Nucleotide5'-NucleotidaseBDNF protein, humanBrain-Derived Neurotrophic FactorDNA-Binding ProteinsNerve Tissue ProteinsNT5C2 protein, humanPolypyrimidine Tract-Binding ProteinPTBP2 protein, humanSEC16B protein, human

Identifiers

PMID35295960
PMCPMC8920651
OpenAlexW4220730664

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.