ArticleBMC pediatrics2022
Sex differences in body composition affect total airway resistance during puberty.
Article in BMC pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Clinical study of bronchial wall area proportion in children and adolescents based on CT images.BMC pulmonary medicine · 2026Article
- Screening for insulin resistance in children with abdominal obesity: sex-specific performance of TyG index, FGIR, and VAI.Physical activity and nutrition · 2026Article
- Age- and Sex-Stratified Population-Based Estimates of Hospitalization-Requiring Asthma Exacerbation in Korea during Prepandemic Period (2002-2019).Respiration; international review of thoracic diseases · 2026Article
- Predicting Minute Ventilation from Heart Rate in Adolescents: A Tool for Environmental Health Studies.Environments (Basel, Switzerland) · 2025Article
- A CBCT Morphometric Study of Hyoid Bone According to Skeletal and Breathing Patterns Using Multi-Factor Robust ANOVA.Healthcare (Basel, Switzerland) · 2025Article
- Short-term exposure to relative humidity and lung health in early adolescents.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring puberty, changes in body composition due to sex hormones are associated with lung mechanics. However, little is known about the mediation effect of sex differences in body composition during puberty with total airway resistance.
methodsWe prospectively recruited 620 children (10-12 years old) from the general population and conducted a cross-sectional study. This study assessed pubertal status according to the five Tanner stages using a questionnaire, line drawings, and each subject's blood sex hormone profile. Both the impulse oscillation system for total lung mechanics and multifrequency bioelectrical impedance for body composition analyses were conducted. The effects of puberty on body composition and subsequent total lung resistance were evaluated using mediation analysis.
resultsAmong the 503 children enrolled, there were 261 males (51.9%) and 242 females (48.1%). In males, higher testosterone levels corresponded with reduced total lung resistance (β = -0.13, 95% CI = -0.21 to -0.05, p < 0.001), and the proportion of the mediating effect through the muscle-fat ratio was 19% (95% CI = 4 to 59, p = 0.02). In contrast, in females, pubertal status reduced total lung resistance (β = -0.27, 95% CI = -0.58 to -0.05, p = 0.04), however, the proportion of the mediating effect through the body mass index was -51% (95% CI = -244 to -4%, p = 0.04).
conclusionThe muscle-fat ratio in adolescent males had a synergistic effect with testosterone on improving total airway resistance, whereas improvements in lung resistance by pubertal status were partially masked by body mass index in adolescent females. In conclusion, body composition changes during puberty between males and females have differing effects on total airway resistance.
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