Evidence map›Paper›PMID 35300967›Full record

ArticleBiophysical journal2022

Oscillations in K(ATP) conductance drive slow calcium oscillations in pancreatic β-cells.

Isabella Marinelli, Benjamin M Thompson, Vishal S Parekh, Patrick A Fletcher, Luca Gerardo-Giorda, Arthur S Sherman, Leslie S Satin, Richard Bertram

Open access · greenAbstract read
In one paragraph

Article in Biophysical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 30 citations in OpenAlex.

  1. GABA Regulates CaMetabolites · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. KThe Journal of physiology · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. CaAmerican journal of physiology. Endocrinology and metabolism · 2023
    Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Isabella MarinelliCentre for Systems Modelling & Quantitative Biomedicine (SMQB), University of Birmingham, Birmingham, UK.
Benjamin M ThompsonDepartment of Pharmacology and Brehm Center for Diabetes Research, University of Michigan Medical School, Ann Arbor, Michigan.
Vishal S ParekhChemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, Massachusetts.
Patrick A FletcherLaboratory of Biological Modeling, National Institutes of Health, Bethesda, Maryland.
Luca Gerardo-GiordaInstitute for Mathematical Methods in Medicine and Data Based Modeling, Johannes Kepler University, Linz, Austria; Johann Radon Institute for Computational and Applied Mathematics (RICAM), Austrian Academy of Sciences, Linz, Austria.
Arthur S ShermanLaboratory of Biological Modeling, National Institutes of Health, Bethesda, Maryland.
Leslie S SatinDepartment of Pharmacology and Brehm Center for Diabetes Research, University of Michigan Medical School, Ann Arbor, Michigan.
Richard BertramDepartment of Mathematics and Programs in Neuroscience and Molecular Biophysics, Florida State University, Tallahassee, Florida. Electronic address: rbertram@fsu.edu.
National Institutes of Health · USUniversity of Michigan · USBroad Institute · USFlorida State University · USJohannes Kepler University of Linz · ATUniversity of Birmingham · GB

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAVID P OLSON · 2013 to 2026
$24.3M
METABOLICALLY-COUPLED ION CHANNEL INTERACTIONS IN ISLETSR01DK046409 · NIDDK · VIRGINIA COMMONWEALTH UNIVERSITY · PI SATIN, LESLIE S. · 1994 to 2023
$9.1M
Stimulus secretion coupling in pancreatic beta-cellsZIADK013027 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI SHERMAN, ARTHUR · 2009 to 2025
$3.6M
NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK046409
6 · The paper itself

Abstract

ATP-sensitive K

Indexed as

Calcium SignalingIslets of LangerhansAdenosine DiphosphateAdenosine TriphosphateAnimalsCalciumGlucoseInsulinMembrane PotentialsMiceAdenosine DiphosphateAdenosine TriphosphateCalciumGlucoseInsulin

Identifiers

PMID35300967
PMCPMC9072586
OpenAlexW4220746953

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.