ArticleJournal of psychiatry & neuroscience : JPN
TGF-β1 is associated with deficits in cognition and cerebral cortical thickness in first-episode schizophrenia.
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Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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19citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 19% of its field
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Altered function of peripheral organ systems in first-episode drug naïve mental illnesses: a systematic review and meta-analysis.Molecular psychiatry · 2026Pooled it
- Relationships Between Immune-Inflammatory Features and Social Cognitive Impairments in Patients With Schizophrenia Spectrum Disorders: A Systematic Review.Brain and behavior · 2025Pooled it
- Prevalent and characteristic alterations in blood-brain transcriptomic-functional imaging coupling in schizophrenia.Molecular psychiatry · 2026Article
- Multi-omics approaches to major psychiatric disorders.Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2026Review
- Recent developments in imaging transcriptomics for psychiatric disorders.Psychoradiology · 2026Review
- Linking Metabolic Disorders and Immune System Phenomena in Schizophrenia: The Role of Adipose Tissue and Inflammation.Biomedicines · 2025Review
- Transforming Growth Factor-β Serum Levels Associated with Social Function in Subjects at Ultra-high Risk for Psychosis: A Multicenter Study.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
- Impact of the Transforming Growth Factor β (TGF-β) on Brain Aneurysm Formation and Development: A Literature Review.Cellular and molecular neurobiology · 2025Review
- Involvement of virus infections and antiviral agents in schizophrenia.Psychological medicine · 2025Review
- Neuroinflammatory Loop in Schizophrenia, Is There a Relationship with Symptoms or Cognition Decline?International journal of molecular sciences · 2025Review
- Relationship of cognitive measures to mRNA levels in lymphocytes from patients with schizophrenia and controls.Schizophrenia research. Cognition · 2024Article
- Immunophenotypes in psychosis: is it a premature inflamm-aging disorder?Molecular psychiatry · 2024Review
- Use of the Chinese version of the MATRICS Consensus Cognitive Battery to assess cognitive functioning in individuals with high risk for psychosis, first-episode schizophrenia and chronic schizophrenia: a systematic review and meta-analysis.The Lancet regional health. Western Pacific · 2024Review
- Cerebrospinal fluid proteomic signatures are associated with symptom severity of first-episode psychosis.Journal of psychiatric research · 2024Article
- Methylome-wide and meQTL analysis helps to distinguish treatment response from non-response and pathogenesis markers in schizophrenia.Frontiers in psychiatry · 2024Article
- Imaging Transcriptomics of the Brain for Schizophrenia.Alpha psychiatry · 2024Review
- Systemic concentrations of IL-18, TFG-β, RANTES, ICAM-1 and uPAR as combined pathway-related factors may help in identification of patients suffering from depressive disorder.Archives of medical science : AMS · 2024Article
- Inflammation and viral infection as disease modifiers in schizophrenia.Frontiers in psychiatry · 2023Review
- Transcriptomics and magnetic resonance imaging in major psychiatric disorders.Frontiers in psychiatry · 2023Review
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 3 countries.
Shujuan PanFrom the Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China (Pan, Zhou, Tong, Li, Huang, Feng, Chen, Yang, S. Tan, Wang, B. Tian, Y. Tan, L. Tian); the Institute of Biomedicine and Translational Medicine, Department of Physiology, Faculty of Medicine, University of Tartu, Tartu, Estonia (Yan, Xuan, L. Tian); the Department of Pharmacy, Peking University First Hospital, Beijing, China (Cui); and the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA (Hong).
Yanfang ZhouFrom the Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China (Pan, Zhou, Tong, Li, Huang, Feng, Chen, Yang, S. Tan, Wang, B. Tian, Y. Tan, L. Tian); the Institute of Biomedicine and Translational Medicine, Department of Physiology, Faculty of Medicine, University of Tartu, Tartu, Estonia (Yan, Xuan, L. Tian); the Department of Pharmacy, Peking University First Hospital, Beijing, China (Cui); and the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA (Hong).
Ling YanFrom the Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China (Pan, Zhou, Tong, Li, Huang, Feng, Chen, Yang, S. Tan, Wang, B. Tian, Y. Tan, L. Tian); the Institute of Biomedicine and Translational Medicine, Department of Physiology, Faculty of Medicine, University of Tartu, Tartu, Estonia (Yan, Xuan, L. Tian); the Department of Pharmacy, Peking University First Hospital, Beijing, China (Cui); and the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA (Hong).
Fangling XuanFrom the Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China (Pan, Zhou, Tong, Li, Huang, Feng, Chen, Yang, S. Tan, Wang, B. Tian, Y. Tan, L. Tian); the Institute of Biomedicine and Translational Medicine, Department of Physiology, Faculty of Medicine, University of Tartu, Tartu, Estonia (Yan, Xuan, L. Tian); the Department of Pharmacy, Peking University First Hospital, Beijing, China (Cui); and the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA (Hong).
Jinghui TongFrom the Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China (Pan, Zhou, Tong, Li, Huang, Feng, Chen, Yang, S. Tan, Wang, B. Tian, Y. Tan, L. Tian); the Institute of Biomedicine and Translational Medicine, Department of Physiology, Faculty of Medicine, University of Tartu, Tartu, Estonia (Yan, Xuan, L. Tian); the Department of Pharmacy, Peking University First Hospital, Beijing, China (Cui); and the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA (Hong).
Yanli LiFrom the Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China (Pan, Zhou, Tong, Li, Huang, Feng, Chen, Yang, S. Tan, Wang, B. Tian, Y. Tan, L. Tian); the Institute of Biomedicine and Translational Medicine, Department of Physiology, Faculty of Medicine, University of Tartu, Tartu, Estonia (Yan, Xuan, L. Tian); the Department of Pharmacy, Peking University First Hospital, Beijing, China (Cui); and the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA (Hong).
Junchao HuangFrom the Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China (Pan, Zhou, Tong, Li, Huang, Feng, Chen, Yang, S. Tan, Wang, B. Tian, Y. Tan, L. Tian); the Institute of Biomedicine and Translational Medicine, Department of Physiology, Faculty of Medicine, University of Tartu, Tartu, Estonia (Yan, Xuan, L. Tian); the Department of Pharmacy, Peking University First Hospital, Beijing, China (Cui); and the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA (Hong).
Wei FengFrom the Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China (Pan, Zhou, Tong, Li, Huang, Feng, Chen, Yang, S. Tan, Wang, B. Tian, Y. Tan, L. Tian); the Institute of Biomedicine and Translational Medicine, Department of Physiology, Faculty of Medicine, University of Tartu, Tartu, Estonia (Yan, Xuan, L. Tian); the Department of Pharmacy, Peking University First Hospital, Beijing, China (Cui); and the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA (Hong).
Song ChenFrom the Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China (Pan, Zhou, Tong, Li, Huang, Feng, Chen, Yang, S. Tan, Wang, B. Tian, Y. Tan, L. Tian); the Institute of Biomedicine and Translational Medicine, Department of Physiology, Faculty of Medicine, University of Tartu, Tartu, Estonia (Yan, Xuan, L. Tian); the Department of Pharmacy, Peking University First Hospital, Beijing, China (Cui); and the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA (Hong).
Yimin CuiFrom the Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China (Pan, Zhou, Tong, Li, Huang, Feng, Chen, Yang, S. Tan, Wang, B. Tian, Y. Tan, L. Tian); the Institute of Biomedicine and Translational Medicine, Department of Physiology, Faculty of Medicine, University of Tartu, Tartu, Estonia (Yan, Xuan, L. Tian); the Department of Pharmacy, Peking University First Hospital, Beijing, China (Cui); and the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA (Hong).
Fude YangFrom the Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China (Pan, Zhou, Tong, Li, Huang, Feng, Chen, Yang, S. Tan, Wang, B. Tian, Y. Tan, L. Tian); the Institute of Biomedicine and Translational Medicine, Department of Physiology, Faculty of Medicine, University of Tartu, Tartu, Estonia (Yan, Xuan, L. Tian); the Department of Pharmacy, Peking University First Hospital, Beijing, China (Cui); and the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA (Hong).
Shuping TanFrom the Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China (Pan, Zhou, Tong, Li, Huang, Feng, Chen, Yang, S. Tan, Wang, B. Tian, Y. Tan, L. Tian); the Institute of Biomedicine and Translational Medicine, Department of Physiology, Faculty of Medicine, University of Tartu, Tartu, Estonia (Yan, Xuan, L. Tian); the Department of Pharmacy, Peking University First Hospital, Beijing, China (Cui); and the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA (Hong).
Zhiren WangFrom the Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China (Pan, Zhou, Tong, Li, Huang, Feng, Chen, Yang, S. Tan, Wang, B. Tian, Y. Tan, L. Tian); the Institute of Biomedicine and Translational Medicine, Department of Physiology, Faculty of Medicine, University of Tartu, Tartu, Estonia (Yan, Xuan, L. Tian); the Department of Pharmacy, Peking University First Hospital, Beijing, China (Cui); and the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA (Hong).
Baopeng TianFrom the Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China (Pan, Zhou, Tong, Li, Huang, Feng, Chen, Yang, S. Tan, Wang, B. Tian, Y. Tan, L. Tian); the Institute of Biomedicine and Translational Medicine, Department of Physiology, Faculty of Medicine, University of Tartu, Tartu, Estonia (Yan, Xuan, L. Tian); the Department of Pharmacy, Peking University First Hospital, Beijing, China (Cui); and the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA (Hong).
L Elliot HongFrom the Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China (Pan, Zhou, Tong, Li, Huang, Feng, Chen, Yang, S. Tan, Wang, B. Tian, Y. Tan, L. Tian); the Institute of Biomedicine and Translational Medicine, Department of Physiology, Faculty of Medicine, University of Tartu, Tartu, Estonia (Yan, Xuan, L. Tian); the Department of Pharmacy, Peking University First Hospital, Beijing, China (Cui); and the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA (Hong).
Yun-Long TanFrom the Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China (Pan, Zhou, Tong, Li, Huang, Feng, Chen, Yang, S. Tan, Wang, B. Tian, Y. Tan, L. Tian); the Institute of Biomedicine and Translational Medicine, Department of Physiology, Faculty of Medicine, University of Tartu, Tartu, Estonia (Yan, Xuan, L. Tian); the Department of Pharmacy, Peking University First Hospital, Beijing, China (Cui); and the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA (Hong) yltan21@126.com li.tian@ut.ee.
Li TianFrom the Peking University Huilongguan Clinical Medical School, Beijing Huilongguan Hospital, Beijing, China (Pan, Zhou, Tong, Li, Huang, Feng, Chen, Yang, S. Tan, Wang, B. Tian, Y. Tan, L. Tian); the Institute of Biomedicine and Translational Medicine, Department of Physiology, Faculty of Medicine, University of Tartu, Tartu, Estonia (Yan, Xuan, L. Tian); the Department of Pharmacy, Peking University First Hospital, Beijing, China (Cui); and the Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, USA (Hong) yltan21@126.com li.tian@ut.ee.
Peking University First Hospital · CNBeijing HuiLongGuan Hospital · CNUniversity of Tartu · EEPeking University · CNUniversity of Maryland, Baltimore · US
Funding
The Role of Stress-Immune-Connectome Disruption in Mechanisms of Chinese Early Schizophrenia SpectrumR01MH112180 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI HONG, L ELLIOT ELLIOT · 2017 to 2021
$1.0MNIMH NIH HHS R01 MH112180
Abstract
backgroundEvidence indicates that cytokines are associated with cognitive deficits in schizophrenia; however, the underlying brain-behaviour mechanisms remain unclear. We hypothesized that aberrations in brain structural connectivity mediate the cytokine effect in schizophrenia.
methodsIn this study, we recruited patients with first-episode schizophrenia (
resultsPatients with schizophrenia had higher TGF-β1 at both the mRNA level (log LIMITATIONS: We did not explore the effect of other blood cytokines on neurocognitive performance and cortical thickness. Participants from the CommonMind Consortium did not all have first-episode schizophrenia and they were not all antipsychotic-naive, so we could not exclude an effect of antipsychotics on TGF-β1 signalling in the dlPFC. The sample size and cross-sectional design of our study were additional limitations.
conclusionThese findings highlighted an association between upregulated blood levels of TGF-β1 and impairments in brain structure and function in schizophrenia.
Indexed as
Antipsychotic AgentsSchizophreniaCognitionCross-Sectional StudiesCytokinesFemaleHumansMagnetic Resonance ImagingMaleTransforming Growth Factor beta1Antipsychotic AgentsCytokinesTGFB1 protein, humanTransforming Growth Factor beta1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.