Evidence map›Paper›PMID 35301367›Full record

ArticleScientific reports2022

Argonaute 2 is lost from neuromuscular junctions affected with amyotrophic lateral sclerosis in SOD1

Dillon Shapiro, Ryan Massopust, Thomas Taetzsch, Gregorio Valdez

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Dillon ShapiroMolecular Biology, Cell Biology, & Biochemistry Graduate Program, Brown University, Providence, RI, USA.
Ryan MassopustDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, 70 Ship St, Providence, RI, 02903, USA.
Thomas TaetzschDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, 70 Ship St, Providence, RI, 02903, USA.
Gregorio ValdezDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, 70 Ship St, Providence, RI, 02903, USA. gregorio_valdez@brown.edu.
Brown University · USAllen Institute for Brain Science · US

Funding

Predoctoral Training in the Molecular Biology of AgingT32AG041688 · NIA · BROWN UNIVERSITY · PI NICOLA NERETTI, John M Sedivy · 2012 to 2026
$3.5M
Targeting the fibroblast growth factor binding protein-1 to slow degeneration of neuromuscular junctionsR01AG055545 · NIA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI VALDEZ, GREGORIO · 2017 to 2021
$2.2M
Analysis of Sensory Neurons to Understand and Identify Factors to Treat ALSR21NS106313 · NINDS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI VALDEZ, GREGORIO · 2018 to 2019
$433k
Synaptic FGFs are required and sufficient to maintain and repair aged NMJsR56AG051501 · NIA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI VALDEZ, GREGORIO · 2015 to 2015
$377k
NIA NIH HHS R01 AG055545NIA NIH HHS R01AG055545NIA NIH HHS R56 AG051501NIA NIH HHS T32 AG041688NINDS NIH HHS R21 NS106313NINDS NIH HHS R21NS106313
6 · The paper itself

Abstract

miRNAs are necessary for neuromuscular junction (NMJ) health; however, little is known about the proteins required for their activity in this regard. We examined expression of Argonaute 2 (Ago2) and miRNA biogenesis genes in skeletal muscles during development, following nerve injury and in the SOD1

Indexed as

Amyotrophic Lateral SclerosisMicroRNAsAnimalsArgonaute ProteinsDisease Models, AnimalMiceMice, TransgenicMuscle, SkeletalNeuromuscular JunctionSuperoxide DismutaseSuperoxide Dismutase-1Ago2 protein, mouseArgonaute ProteinsMicroRNAsSuperoxide DismutaseSuperoxide Dismutase-1

Identifiers

PMID35301367
PMCPMC8931107
OpenAlexW4220896256

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.