Evidence map›Paper›PMID 35301677›Full record

Trial reportJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2023

Fully automated deep learning powered calcium scoring in patients undergoing myocardial perfusion imaging.

Thomas Sartoretti, Antonio G Gennari, Elisabeth Sartoretti, Stephan Skawran, Alexander Maurer, Ronny R Buechel, Michael Messerli

Registry-linked trialOpen access · hybridAbstract readClinical Trial
In one paragraph

Trial report in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03637231 (Ultra-low-dose Coronary Artery Calcium Scoring), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03637231 naterminatednot on this map

Ultra-low-dose Coronary Artery Calcium Scoring: Evaluation of Prognostic Performance and Impact of Physiological Factors on Quantification in a Large Population

TypeinterventionalSponsorUniversity of ZurichRan2018 to 2021Enrolled301ConditionsCoronary Artery DiseaseArmsUltra low-dose CTAC
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Deep Learning Coronary Artery Calcium Scores from SPECT/CT Attenuation Maps Improve Prediction of Major Adverse Cardiac Events.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  7. Article
  8. Article
  9. Artificial intelligence for disease diagnosis and risk prediction in nuclear cardiology.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Review
  10. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Thomas SartorettiDepartment of Nuclear Medicine, University Hospital Zurich / University of Zurich, Ramistrasse 100, 8091, Zurich, Switzerland.
Antonio G GennariDepartment of Nuclear Medicine, University Hospital Zurich / University of Zurich, Ramistrasse 100, 8091, Zurich, Switzerland.
Elisabeth SartorettiDepartment of Nuclear Medicine, University Hospital Zurich / University of Zurich, Ramistrasse 100, 8091, Zurich, Switzerland.
Stephan SkawranDepartment of Nuclear Medicine, University Hospital Zurich / University of Zurich, Ramistrasse 100, 8091, Zurich, Switzerland.
Alexander MaurerDepartment of Nuclear Medicine, University Hospital Zurich / University of Zurich, Ramistrasse 100, 8091, Zurich, Switzerland.
Ronny R BuechelDepartment of Nuclear Medicine, University Hospital Zurich / University of Zurich, Ramistrasse 100, 8091, Zurich, Switzerland.
Michael MesserliDepartment of Nuclear Medicine, University Hospital Zurich / University of Zurich, Ramistrasse 100, 8091, Zurich, Switzerland. michael.messerli@usz.ch.
University Hospital of Zurich · CHUniversity of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo assess the accuracy of fully automated deep learning (DL) based coronary artery calcium scoring (CACS) from non-contrast computed tomography (CT) as acquired for attenuation correction (AC) of cardiac single-photon-emission computed tomography myocardial perfusion imaging (SPECT-MPI). METHODS AND

resultsPatients were enrolled in this study as part of a larger prospective study (NCT03637231). In this study, 56 Patients who underwent cardiac SPECT-MPI due to suspected coronary artery disease (CAD) were prospectively enrolled. All patients underwent non-contrast CT for AC of SPECT-MPI twice. CACS was manually assessed (serving as standard of reference) on both CT datasets (n = 112) and by a cloud-based DL tool. The agreement in CAC scores and CAC score risk categories was quantified. For the 112 scans included in the analysis, interscore agreement between the CAC scores of the standard of reference and the DL tool was 0.986. The agreement in risk categories was 0.977 with a reclassification rate of 3.6%. Heart rate, image noise, body mass index (BMI), and scan did not significantly impact (p=0.09 - p=0.76) absolute percentage difference in CAC scores.

conclusionA DL tool enables a fully automated and accurate estimation of CAC scores in patients undergoing non-contrast CT for AC of SPECT-MPI.

Indexed as

Coronary Artery DiseaseDeep LearningMyocardial Perfusion ImagingCalciumHumansProspective StudiesTomography, Emission-Computed, Single-PhotonCalciumAtherosclerosisCADCTDiagnostic and prognostic applicationSPECT

Identifiers

PMID35301677
PMCPMC9984313
OpenAlexW4220753055

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.