ArticleScience immunology2022
Allergic airway recall responses require IL-9 from resident memory CD4
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Article in Science immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40citing papers in PubMed
6.1field-weighted citation impact, top 2% of its field
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Who cites it
40 citing papers in PubMed, 54 citations in OpenAlex.
- Progenitor T cells drive chronic pulmonary type 2 inflammation.Nature immunology · 2026Article
- IL-9 Is Essential for ILC2-Mediated but Not Th2- and Th17-Cell-Mediated Allergic Airway Inflammation in Mice.European journal of immunology · 2026Article
- Article
- CD69 regulates the tissue dynamics of epigenetically imprinted memory CD4Science advances · 2026Article
- Inflammatory memory: the core mechanism driving allergic asthma recurrence and chronicity.Journal of thoracic disease · 2026Review
- The Pleiotropic IL-9 Network in Asthma Pathogenesis and Targeted Therapy.Journal of inflammation research · 2026Review
- The immunology of asthma.Nature immunology · 2025Review
- Naturally derived bioactive compounds as regulators of oxidative stress and inflammation in asthma.Chinese medicine · 2025Review
- Recurrence of acute allergic asthma depends on the role of ILC2 driven by Il1rl1 signaling.Cell communication and signaling : CCS · 2025Article
- Innate Immunity and Asthma Exacerbations: Insights From Human Models.Immunological reviews · 2025Review
- Tissue-Resident Th2 Cells in Type 2 Immunity and Allergic Diseases.Immunological reviews · 2025Review
- IL-33 signaling is dispensable for the IL-10-induced enhancement of mast cell responses during food allergy.Frontiers in immunology · 2025Article
- Regional specialization within the mammalian respiratory immune system.Trends in immunology · 2024Review
- IL-2 family cytokines IL-9 and IL-21 differentially regulate innate and adaptive type 2 immunity in asthma.The Journal of allergy and clinical immunology · 2024Article
- A Prime-Boost Vaccination Approach Induces Lung Resident Memory CD8+ T Cells Derived from Central Memory T Cells That Prevent Tumor Lung Metastasis.Cancer research · 2024Article
- Activin A Promotes Differentiation of a Pathogenic Multicytokine IL-9-secreting CD4+ T Cell Population.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Heterogeneous IL-9 Production by Circulating Skin-Tropic and Extracutaneous Memory T Cells in Atopic Dermatitis Patients.International journal of molecular sciences · 2024Article
- TL1A priming induces a multi-cytokine Th9 cell phenotype that promotes robust allergic inflammation in murine models of asthma.Mucosal immunology · 2024Article
- TL1A is an epithelial alarmin that cooperates with IL-33 for initiation of allergic airway inflammation.The Journal of experimental medicine · 2024Article
- IL-10 Neutralization Attenuates Mast Cell Responses in a Murine Model of Experimental Food Allergy.ImmunoHorizons · 2024Article
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 2 countries.
Benjamin J UlrichDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-2729-1798
Rakshin KharwadkarDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Michelle ChuDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-0331-6118
Abigail PajulasDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Charanya MuralidharanDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Byunghee KohDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-3554-4449
Yongyao FuDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-0739-0035
Hongyu GaoDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Tristan A HayesDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-0532-5536
Hong-Ming ZhouDepartment of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-8006-210X
Nick P GoplenThoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, Rochester, MN 55902, USA.ORCID 0000-0003-4614-5996
Andrew S NelsonDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-5107-2168
Yunlong LiuDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-2699-626X
Amelia K LinnemannDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-7356-4876
Matthew J TurnerDepartment of Dermatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-5394-0923
Paula Licona-LimónDepartamento de Biologia Celular y del Desarrollo, Instituto de Fisiologia Celular, Universidad Nacional Autónoma de México, Mexico City 04020, Mexico.ORCID 0000-0002-7692-8900
Richard A FlavellDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0003-4461-0778
Jie SunThoracic Diseases Research Unit, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Department of Immunology, Mayo Clinic College of Medicine and Science, Rochester, Rochester, MN 55902, USA.ORCID 0000-0002-2347-4511
Mark H KaplanDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-2923-8245
Indiana University School of MedicineMayo Clinic · USRichard L. Roudebush VA Medical Center · USHoward Hughes Medical Institute · USUniversidad Nacional Autónoma de México · MX
Funding
Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI David W Clapp · 1999 to 2026
$59.3MQuality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2MProject-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7MThe role of PU.1 in T helper cell heterogeneityR01AI057459 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI KAPLAN, MARK H · 2005 to 2025
$8.2MImmunology and Infectious Diseases Training ProgramT32AI060519 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI MARK H KAPLAN · 2004 to 2026
$6.0MIndiana Medical Scientist/Engineer Training ProgramT32GM077229 · NIGMS · INDIANA UNIVERSITY INDIANAPOLIS · PI GASTON, BENJAMIN, HERBERT, BRITTNEY-SHEA · 2008 to 2022
$6.0MHost cellular network governing the development of post SARS-CoV-2 tissue sequelaeR01AI147394 · NIAID · UNIVERSITY OF VIRGINIA · PI Jie Sun · 2020 to 2026
$4.7MElucidating the roles of alveolar macrophage inflammation and selfrenewal during influenza infectionR01AG069264 · NIA · UNIVERSITY OF VIRGINIA · PI Jie Sun · 2020 to 2026
$3.5MTh9 cells in immediate hypersensitivityR01AI129241 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI KAPLAN, MARK H · 2017 to 2021
$2.0MIL-9-dependent interstitial macrophage function in the allergic lungR56AI129241 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI KAPLAN, MARK H · 2023 to 2023
$461kIL-9-secreting tissue-resident memory T cells in allergic airway diseaseF30HL147515 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI ULRICH, BENJAMIN · 2019 to 2019
$30kRole of keratinocyte-derived cytokines in epidermal injury and atopic dermatitisIK2CX001019 · VA · RLR VA MEDICAL CENTER · PI TURNER, MATTHEW J · 2016 to 2021
–CSRD VA I01 CX002141CSRD VA IK2 CX001019NCATS NIH HHS UL1 TR002529NCI NIH HHS P30 CA082709NHLBI NIH HHS F30 HL147515NIAID NIH HHS R01 AI057459NIAID NIH HHS R01 AI129241NIAID NIH HHS R01 AI147394NIAID NIH HHS R56 AI129241NIAID NIH HHS T32 AI060519NIA NIH HHS R01 AG069264NIDDK NIH HHS U54 DK106846NIGMS NIH HHS T32 GM077229
Abstract
Asthma is a chronic inflammatory lung disease with intermittent flares predominately mediated through memory T cells. Yet, the identity of long-term memory cells that mediate allergic recall responses is not well defined. In this report, using a mouse model of chronic allergen exposure followed by an allergen-free rest period, we characterized a subpopulation of CD4
Indexed as
AsthmaHypersensitivityAllergensCD4-Positive T-LymphocytesCytokinesHumansInflammationInterleukin-9AllergensCytokinesInterleukin-9
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.