Evidence map›Paper›PMID 35303418›Full record

ArticleCurrent biology : CB2022

Chloride oscillation in pacemaker neurons regulates circadian rhythms through a chloride-sensing WNK kinase signaling cascade.

Jeffrey N Schellinger, Qifei Sun, John M Pleinis, Sung-Wan An, Jianrui Hu, Gaëlle Mercenne, Iris Titos, Chou-Long Huang, Adrian Rothenfluh, Aylin R Rodan

Open access · greenAbstract read
In one paragraph

Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Function and regulation of the insect NaCCC2 sodium transport proteins.Comparative biochemistry and physiology. Part A, Molecular & integrative physiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jeffrey N SchellingerDepartment of Internal Medicine, Division of Nephrology, University of Texas Southwestern, Dallas, TX 75390, USA.
Qifei SunDepartment of Internal Medicine, Division of Nephrology, University of Texas Southwestern, Dallas, TX 75390, USA.
John M PleinisMolecular Medicine Program, University of Utah, Salt Lake City, UT 84112, USA.
Sung-Wan AnDepartment of Internal Medicine, Division of Nephrology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Jianrui HuMolecular Medicine Program, University of Utah, Salt Lake City, UT 84112, USA.
Gaëlle MercenneMolecular Medicine Program, University of Utah, Salt Lake City, UT 84112, USA.
Iris TitosMolecular Medicine Program, University of Utah, Salt Lake City, UT 84112, USA.
Chou-Long HuangDepartment of Internal Medicine, Division of Nephrology, University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA.
Adrian RothenfluhMolecular Medicine Program, University of Utah, Salt Lake City, UT 84112, USA; Department of Psychiatry, Huntsman Mental Health Institute, University of Utah, Salt Lake City, UT 84108, USA; Department of Neurobiology, University of Utah, Salt Lake City, UT 84112, USA; Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA.
Aylin R RodanMolecular Medicine Program, University of Utah, Salt Lake City, UT 84112, USA; Department of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA; Department of Internal Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT 84132, USA; Medical Service, Veterans Affairs Salt Lake City Health Care System, Salt Lake City, UT 84148, USA. Electronic address: aylin.rodan@hsc.utah.edu.
University of Utah · USThe University of Texas Southwestern Medical Center · USUniversity of Iowa · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
DROSOPHILA GENOMICS RESOURCE CENTERP40OD010949 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Andrew Zelhof · 2012 to 2026
$9.4M
Control of Alcohol Responses by Actin-Regulating GenesR01AA019526 · NIAAA · UT SOUTHWESTERN MEDICAL CENTER · PI ROTHENFLUH, ADRIAN · 2010 to 2025
$5.4M
Regulation of WNK signaling by potassium and Mo25: structure, function and physiologyR01DK110358 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI RODAN, AYLIN RACHEL · 2016 to 2025
$4.1M
WNK kinase cascade in health and diseaseR01DK111542 · NIDDK · UNIVERSITY OF IOWA · PI Chou-Long Huang · 2017 to 2026
$3.6M
Mechanisms of alcohol-induced plasticitey mediated by Arf6R01AA026818 · NIAAA · UNIVERSITY OF UTAH · PI ROTHENFLUH, ADRIAN · 2018 to 2022
$1.7M
WNK & SPAK/OSR1 regulation of SLC12 cotransporters in DrosophilaK08DK091316 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI RODAN, AYLIN RACHEL · 2011 to 2015
$727k
ATAC-ing dopaminergic cell identity with single-cell resolutionR21DA049635 · NIDA · UNIVERSITY OF UTAH · PI ROTHENFLUH, ADRIAN · 2019 to 2020
$419k
Probing intracellular Cl- in a WNK signaling-dependent transporting epitheliumR03DK106350 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI RODAN, AYLIN RACHEL · 2015 to 2016
$156k
NIAAA NIH HHS R01 AA019526NIAAA NIH HHS R01 AA026818NIDA NIH HHS R21 DA049635NIDDK NIH HHS K08 DK091316NIDDK NIH HHS R01 DK110358NIDDK NIH HHS R01 DK111542NIDDK NIH HHS R03 DK106350NIH HHS P40 OD010949NIH HHS P40 OD018537
6 · The paper itself

Abstract

Central pacemaker neurons regulate circadian rhythms and undergo diurnal variation in electrical activity in mammals and flies.

Indexed as

Drosophila melanogasterDrosophila ProteinsAnimalsChloridesCircadian RhythmMammalsNeuronsProtein Serine-Threonine KinasesSignal TransductionChloridesDrosophila Proteinsfray protein, DrosophilaProtein Serine-Threonine KinasesWNK protein, Drosophilachloride signalingcircadian rhythmDrosophilaFrayKCCNKCCpotassium channelSLC12SPAKWNK

Identifiers

PMID35303418
PMCPMC8972083
OpenAlexW4221108730

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.