SynthesisTranslational psychiatry2022
Phenotypic and genetic analysis of a wellbeing factor score in the UK Biobank and the impact of childhood maltreatment and psychiatric illness.
Synthesis in Translational psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- The Association of Environmental Variables with Intelligence and Well-Being in Copy Number Variation (CNV) Carriers.Research square · 2026Article
- Integrating genomic structural equation modeling and experimental validation to unravel the genetic basis of male genital lichen sclerosus.Frontiers in immunology · 2026Article
- Ethnicity, subjective wellbeing, and cardiovascular disease: insights from path and machine learning analyses using data from the UK biobank.BMC public health · 2025Article
- Ethnic-Specific Threshold Analysis and BMI and Waist Circumference Cutoffs for Cardiovascular Disease and Subjective Wellbeing: Results using Data from the UK Biobank.Journal of racial and ethnic health disparities · 2025Article
- Using genomic structural equation modeling to examine the genetic architecture of PTSD and life satisfaction phenotypes.European journal of psychotraumatology · 2025Article
- Article
- The association between metabolite concentrations and wellbeing in adults.Scientific reports · 2025Article
- Endophenotype 2.0: updated definitions and criteria for endophenotypes of psychiatric disorders, incorporating new technologies and findings.Translational psychiatry · 2024Review
- Well-Being and Cardiovascular Health: Insights From the UK Biobank Study.Journal of the American Heart Association · 2024Article
- Principled distillation of UK Biobank phenotype data reveals underlying structure in human variation.Nature human behaviour · 2024Article
- Measuring mental wellbeing in clinical and non-clinical adolescents using the COMPAS-W Wellbeing Scale.Frontiers in psychiatry · 2024Article
- Childhood adversity severity modulates the associations between adaptive psychological changes and amygdala volumetric changes in response to behavioral interventions.Journal of affective disorders reports · 2024Article
- Functional Variation in theGenes · 2023Article
- Genetic associations between alcohol phenotypes and life satisfaction: a genomic structural equation modelling approach.Scientific reports · 2023Article
- Wellbeing and brain structure: A comprehensive phenotypic and genetic study of image-derived phenotypes in the UK Biobank.Human brain mapping · 2022Review
- College students' screening early warning factors in identification of suicide risk.Frontiers in genetics · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Wellbeing is an important aspect of mental health that is moderately heritable. Specific wellbeing-related variants have been identified via GWAS meta-analysis of individual questionnaire items. However, a multi-item within-subject index score has potential to capture greater heritability, enabling improved delineation of genetic and phenotypic relationships across traits and exposures that are not possible on aggregate-data. This research employed data from the UK Biobank resource, and a wellbeing index score was derived from indices of happiness and satisfaction with family/friendship/finances/health, using principal component analysis. GWAS was performed in Caucasian participants (N = 129,237) using the derived wellbeing index, followed by polygenic profiling (independent sample; N = 23,703). The wellbeing index, its subcomponents, and negative indicators of mental health were compared via phenotypic and genetic correlations, and relationships with psychiatric disorders examined. Lastly, the impact of childhood maltreatment on wellbeing was investigated. Five independent genome-wide significant loci for wellbeing were identified. The wellbeing index had SNP-heritability of ~8.6%, and stronger phenotypic and genetic correlations with its subcomponents (0.55-0.77) than mental health phenotypes (-0.21 to -0.39). The wellbeing score was lower in participants reporting various psychiatric disorders compared to the total sample. Childhood maltreatment exposure was also associated with reduced wellbeing, and a moderate genetic correlation (r
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