Evidence map›Paper›PMID 35304603›Full record

ReviewNature reviews. Endocrinology2022

Exerkines in health, resilience and disease.

Lisa S Chow, Robert E Gerszten, Joan M Taylor, Bente K Pedersen, Henriette van Praag, Scott Trappe, Mark A Febbraio, Zorina S Galis, Yunling Gao, Jacob M Haus and 15 more

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07473440 (MYOSTATIN REDUCTION WITHIN THE MYOKINE-ADIPOKINE NETWORK PREDICTS AEROBIC ADAPTATION AFTER HIGH-INTENSITY INTERVAL TRAINING IN COMBAT ATHLETES), which is not on this map. Cited by 543 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
543citing papers in PubMed, 8 pooled it
87.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07473440 nacompletednot on this mapstarted 2025, after this paper: background citation

Myostatin reduction within the myokine-adipokine network predicts aerobic adaptation after high-intensity interval training in combat athletes

TypeinterventionalSponsorAdiyaman UniversityRan2025 to 2025Enrolled40ConditionsExercise Adaptation, Aerobic Capacity, Athletic Performance, Combat Sports TrainingArmsSPORT-SPECIFIC CONDITIONING PROGRAM
3 · Its place in the literature

Who cites it

543 citing papers in PubMed, 8 syntheses or guidelines pooled it, 797 citations in OpenAlex.

  1. Pooled it
  2. Circulating Myokine Responses to Acute Endurance Exercise and Their Role in Immunoregulation: A Systematic Review and Meta-Analysis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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  14. Dynamic Metabolic Changes Driven by Exercise Intensity in Acute Swimming.Medicine and science in sports and exercise · 2025
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483 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors at 20 institutions in 7 countries.

Lisa S ChowDivision of Diabetes Endocrinology and Metabolism, University of Minnesota, Minneapolis, MN, USA. chow0007@umn.edu.ORCID http://orcid.org/0000-0002-6210-2307
Robert E GersztenDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6767-7687
Joan M TaylorDepartment of Pathology, McAllister Heart Institute, University of North Carolina, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-8794-5167
Bente K PedersenCentre of Inflammation and Metabolism/Centre for PA Research (CIM/CFAS), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-6508-6288
Henriette van PraagStiles-Nicholson Brain institute and Charles E. Schmidt College of Medicine, Florida Atlantic University, Jupiter, FL, USA.ORCID http://orcid.org/0000-0002-5727-434X
Scott TrappeHuman Performance Laboratory, Ball State University, Muncie, IN, USA.ORCID http://orcid.org/0000-0002-6438-431X
Mark A FebbraioMonash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0002-9296-4418
Zorina S GalisDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-6686-4766
Yunling GaoDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Jacob M HausSchool of Kinesiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-8048-2470
Ian R LanzaDivision of Endocrinology, Nutrition, and Metabolism, Mayo Clinic College of Medicine and Science, Rochester, MN, USA.
Carl J LavieDivision of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School-the University of Queensland School of Medicine, New Orleans, LA, USA.
Chih-Hao LeeDepartment of Molecular Metabolism, Harvard T.H. Chan School of Public Health, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6090-0786
Alejandro LuciaFaculty of Sport Sciences, Universidad Europea de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0002-5565-0997
Cedric MoroInstitute of Metabolic and Cardiovascular Diseases, Team MetaDiab, Inserm UMR1297, Toulouse, France.ORCID http://orcid.org/0000-0003-4294-0597
Ambarish PandeyDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
Jeremy M RobbinsDivision of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9672-4841
Kristin I StanfordDepartment of Physiology and Cell Biology, Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University College of Medicine, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-0681-7746
Alice E ThackrayNational Centre for Sport and Exercise Medicine, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK.ORCID http://orcid.org/0000-0002-7800-3207
Saul VilledaDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-2726-9582
Matthew J WattDepartment of Anatomy and Physiology, School of Biomedical Sciences, The University of Melbourne, Victoria, Australia.
Ashley XiaDivision of Diabetes, Endocrinology, & Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-9534-8506
Juleen R ZierathDepartment of Molecular Medicine and Surgery, Section for Integrative Physiology, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-6891-7497
Bret H GoodpasterTranslational Research Institute, AdventHealth, Orlando, FL, USA. bret.goodpaster@adventhealth.com.ORCID http://orcid.org/0000-0003-1275-5147
Michael P SnyderDepartment of Genetics, Stanford School of Medicine, Stanford, CA, USA. mpsnyder@stanford.edu.
National Institutes of Health · USBeth Israel Deaconess Medical Center · USUniversity of Copenhagen · DKAdventHealth Orlando · USBall State University · USFlorida Atlantic University · USHarvard University · USLoughborough University · GBMayo Clinic · USMonash University · AUResearch Institute Hospital 12 de Octubre · ESSouthwestern Medical Center · USStanford Medicine · USThe Ohio State University · USThe University of Melbourne · AUUniversité Toulouse III - Paul Sabatier · FRUniversity of California, San Francisco · USUniversity of Michigan · USUniversity of Minnesota · USUniversity of North Carolina at Chapel Hill · US

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Scott Soleimanpour · 2013 to 2026
$24.3M
Stanford/Salk MoTrPAC Site for Genomes, Epigenomes and TranscriptomesU24DK112348 · NIDDK · STANFORD UNIVERSITY · PI Stephen Montgomery, MICHAEL P. SNYDER · 2017 to 2026
$18.4M
The Exercise and Physical Activity Collaborative Team (ExPACT): a Proposed MoTrPAC Clinical CenterU01AR071133 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BUFORD, THOMAS W, GOODPASTER, BRET H · 2017 to 2024
$16.7M
Longitudinal Multiomics Microbial Profiling in Healthy and Disease IndividualsU54DK102556 · NIDDK · STANFORD UNIVERSITY · PI SNYDER, MICHAEL P., WEINSTOCK, GEORGE M · 2014 to 2015
$7.7M
BAT as a therapeutic for the metabolic and cardiac dysfunction with senescence.R01AG060542 · NIA · OHIO STATE UNIVERSITY · PI COEN, PAUL MARTIN, STANFORD, KRISTIN I · 2019 to 2023
$3.0M
Atheroprotection by smooth muscle selective RhoGAPsR01HL165786 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MACK, CHRISTOPHER P., TAYLOR, JOAN M · 2022 to 2025
$2.9M
Training Effects on Skeletal Muscle Lipid DynamicsR01DK098203 · NIDDK · UNIVERSITY OF MINNESOTA · PI CHOW, LISA SENYE · 2014 to 2018
$2.7M
A Novel Role for Brown Adipose Tissue Enhance Heart Function and MetabolismR01HL138738 · NHLBI · OHIO STATE UNIVERSITY · PI STANFORD, KRISTIN I · 2017 to 2021
$2.3M
Molecular Control of Cardiomyocyte Mitophagy by the RhoGAP GRAF1R01HL142879 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TAYLOR, JOAN M · 2020 to 2023
$1.8M
DMGV and the AGXT2 pathway in chronic exercise-induced cardiometabolic adaptations.K23HL150327 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ROBBINS, JEREMY · 2020 to 2024
$850k
Evaluation of Racial Differences in Cardiorespiratory Fitness Decline with Aging & Underlying Biological MechanismsR03AG067960 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI PANDEY, AMBARISH · 2020 to 2021
$327k
Department of HealthNHLBI NIH HHS K23 HL150327NHLBI NIH HHS R01 HL138738NHLBI NIH HHS R01 HL142879NHLBI NIH HHS R01 HL165786NIAMS NIH HHS U01 AR071133NIA NIH HHS R01 AG060542NIA NIH HHS R03 AG067960NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK040561NIDDK NIH HHS R01 DK098203NIDDK NIH HHS U24 DK112348NIDDK NIH HHS U54 DK102556
6 · The paper itself

Abstract

The health benefits of exercise are well-recognized and are observed across multiple organ systems. These beneficial effects enhance overall resilience, healthspan and longevity. The molecular mechanisms that underlie the beneficial effects of exercise, however, remain poorly understood. Since the discovery in 2000 that muscle contraction releases IL-6, the number of exercise-associated signalling molecules that have been identified has multiplied. Exerkines are defined as signalling moieties released in response to acute and/or chronic exercise, which exert their effects through endocrine, paracrine and/or autocrine pathways. A multitude of organs, cells and tissues release these factors, including skeletal muscle (myokines), the heart (cardiokines), liver (hepatokines), white adipose tissue (adipokines), brown adipose tissue (baptokines) and neurons (neurokines). Exerkines have potential roles in improving cardiovascular, metabolic, immune and neurological health. As such, exerkines have potential for the treatment of cardiovascular disease, type 2 diabetes mellitus and obesity, and possibly in the facilitation of healthy ageing. This Review summarizes the importance and current state of exerkine research, prevailing challenges and future directions.

Indexed as

Diabetes Mellitus, Type 2AdipokinesExerciseHumansMuscle, SkeletalObesityAdipokines

Identifiers

PMID35304603
PMCPMC9554896
OpenAlexW4220828826

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.