ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2023
Consumption of Ultra-Processed Food and Cognitive Decline among Older Adults With Type-2 Diabetes.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Ultraprocessed Food Intake, Cognition, and Executive Function in Adults: A Systematic Review.Nutrients · 2026Pooled it
- Consumption of ultra-processed foods and risk for Alzheimer's disease: a systematic review.Frontiers in nutrition · 2023Pooled it
- Ultra-Processed Foods, MASLD, and Cognitive Aging: A Processing-Centered Gut-Liver-Brain Axis Perspective.Nutrients · 2026Review
- The association between ultra-processed food exposure and cognition in older adults.GeroScience · 2026Article
- Ultra-processed foods and accelerated aging in adults: an emerging public health challenge for nutrition and functional health.Frontiers in nutrition · 2026Review
- Western Diet and Cognitive Decline: A Hungarian Perspective-Implications for the Design of the Semmelweis Study.Nutrients · 2025Review
- Differential association of ultraprocessed food categories with risk of developing cognitive impairment in middle-aged and older adults in a longitudinal panel study.The American journal of clinical nutrition · 2025Article
- Ultra-processed food consumption and risk of dementia and Alzheimer's disease: The Framingham Heart Study.The journal of prevention of Alzheimer's disease · 2025Article
- Article
- Ultra-processed foods consumption among a USA representative sample of middle-older adults: a cross-sectional analysis.The British journal of nutrition · 2024Article
- [Association of ultra-processed food with diabetes and impaired fasting glucose in elderly populations (urban and rural): a cross-sectional study].Korean journal of community nutrition · 2024Article
- Association Between Ultra-Processed Food Consumption and Cognitive Performance Among Adolescent Students From Underdeveloped Cities in Brazil: A Cross-Sectional Study.International journal of public health · 2024Article
- Industrial Use of Phosphate Food Additives: A Mechanism Linking Ultra-Processed Food Intake to Cardiorenal Disease Risk?Nutrients · 2023Review
- The relationship between dietary patterns derived from inflammation and cognitive impairment in patients undergoing hemodialysis.Frontiers in nutrition · 2023Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundUltra-processed food (UPF) consumption is related to increased morbidity and mortality. However, knowledge on its association with cognitive function is lacking. In this longitudinal study, we examined the associations between UPF intake and cognitive decline in older adults with type-2 diabetes (T2D).
methodsThe sample included initially nondemented T2D older adults (≥65 years), from the Israel Diabetes and Cognitive Decline study, who had complete information on nutrition at baseline and at least 3 cognitive assessments (mean follow-up 5.3 ± 1.5 years). Nutritional intake was evaluated by a validated Food-Frequency Questionnaire, and foods were categorized as UPF based on NOVA classification. Percent of calories from UPF were calculated from total caloric consumption in total and specific food groups. Mixed effect models were used to examine the link between UPF intake (top vs bottom quartiles) and change in cognitive function overall and in specific domains, adjusting for potential confounders.
resultsOf the total sample (N = 568; mean age 71.3 ± 4.5 years, 60% men), 141 consumed >31% kcal from UPF (top quartile). Greater intake of ultra-processed meat was associated with a faster decline in executive functions and global cognition (β = -0.041 ± 0.013; p = .002 and β = -0.026 ± 0.010; p = .011, respectively). Additionally, consumption of ultra-processed oils/spreads was associated with faster decline in executive functions and global cognition (β = -0.037 ± 0.014; p = .006 and β = -0.028 ± 0.010; p = .009, respectively). Total UPF consumption and UPF-derived from dairy products and bread/pastries/starch were not associated with cognitive change.
conclusionThis study suggests that a high intake of ultra-processed meat and oils/spreads may be associated with accelerated cognitive decline in older individuals with T2D.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.