Evidence map›Paper›PMID 35305142›Full record

ReviewEuropean journal of applied physiology2022

The impact of different forms of exercise on endothelial progenitor cells in healthy populations.

Panagiotis Ferentinos, Costas Tsakirides, Michelle Swainson, Adam Davison, Marrissa Martyn-St James, Theocharis Ispoglou

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European journal of applied physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Panagiotis FerentinosCarnegie School of Sport, Leeds Beckett University, Leeds, UK.
Costas TsakiridesCarnegie School of Sport, Leeds Beckett University, Leeds, UK.
Michelle SwainsonLancaster Medical School, Faculty of Health and Medicine, Lancaster University, Lancaster, UK.
Adam DavisonFlow Cytometry Facility, Leeds Institute of Cancer and Pathology, University of Leeds, St James's University Hospital, Leeds, UK.
Marrissa Martyn-St JamesSchool of Health and Related Research, University of Sheffield, Sheffield, UK.
Theocharis IspoglouCarnegie School of Sport, Leeds Beckett University, Leeds, UK. t.ispoglou@leedsbeckett.ac.uk.ORCID http://orcid.org/0000-0002-7608-6512
Leeds Beckett University · GBLancaster University · GBUniversity of Leeds · GBUniversity of Sheffield · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating endothelial progenitor cells (EPCs) contribute to vascular healing and neovascularisation, while exercise is an effective means to mobilise EPCs into the circulation.

objectivesto systematically examine the acute and chronic effects of different forms of exercise on circulating EPCs in healthy populations.

methodsPreferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were followed.

resultsthirty-one articles met the inclusion criteria including 747 participants aged 19 to 76 years. All included trials used flow cytometry for identification of circulating EPCs. Eight and five different EPC phenotypes were identified in the acute and chronic trials, respectively. In the acute trials, moderate intensity continuous (MICON), maximal, prolonged endurance, resistance and high intensity interval training (HIIT) exercise protocols were utilised. Prolonged endurance and resistance exercise had the most profound effect on circulating EPCs followed by maximal exercise. In the chronic trials, MICON exercise, HIIT, HIIT compared to MICON and MICON compared to exergame (exercise modality based on an interactive video game) were identified. MICON exercise had a positive effect on circulating EPCs in older sedentary individuals which was accompanied by improvements in endothelial function and arterial stiffness. Long-stage HIIT (4 min bouts) appears to be an effective means and superior than MICON exercise in mobilising circulating EPCs. In conclusion, both in acute and chronic trials the degree of exercise-induced EPC mobilisation depends upon the exercise regime applied. In future, more research is warranted to examine the dose-response relationship of different exercise forms on circulating EPCs using standardised methodology and EPC phenotype.

Indexed as

Endothelial Progenitor CellsHigh-Intensity Interval TrainingAgedExerciseExercise TherapyFlow CytometryHumansAerobic trainingCardiometabolic healthEndothelial progenitor cellsEPC mobilisationExerciseFlow cytometryHigh intensity interval trainingModerate intensity continuous trainingResistance exerciseVascular health

Identifiers

PMID35305142
PMCPMC9197818
OpenAlexW4220883040

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.