ArticleAbdominal radiology (New York)2022
Detection of fatty liver using virtual non-contrast dual-energy CT.
Article in Abdominal radiology (New York), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- From Molecular Mechanisms to Clinical Strategies: A Comprehensive Overview of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).International journal of molecular sciences · 2026Review
- Imaging Evaluation for Steatotic Liver Disease.Korean journal of radiology · 2026Review
- Spectral optimization using fast kV switching and filtration for photon counting CT with realistic detector responses: a simulation study.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Non-invasively differentiate non-alcoholic steatohepatitis by visualizing hepatic integrin αvβ3 expression with a targeted molecular imaging modality.World journal of hepatology · 2024Article
- Post-contrast CT liver attenuation alone is superior to the liver-spleen difference for identifying moderate hepatic steatosis.European radiology · 2024Article
- Virtual Non-Contrast versus True Native in Photon-Counting CT: Stability of Density of Upper Abdominal Organs and Vessels.Diagnostics (Basel, Switzerland) · 2024Article
- Dual-Energy CT in Oncologic Imaging.Tomography (Ann Arbor, Mich.) · 2024Review
- CT-based methods for assessment of metabolic dysfunction associated with fatty liver disease.European radiology experimental · 2023Review
- Non-Invasive Imaging Methods to Evaluate Non-Alcoholic Fatty Liver Disease with Fat Quantification: A Review.Diagnostics (Basel, Switzerland) · 2023Review
- Spectral CT: Current Liver Applications.Diagnostics (Basel, Switzerland) · 2023Review
- Non-invasive imaging biomarkers for liver steatosis in non-alcoholic fatty liver disease: present and future.Clinical and molecular hepatology · 2023Review
- CT Texture Analysis in Nonalcoholic Fatty Liver Disease (NAFLD).Journal of clinical and experimental hepatologyArticle
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3 authors.
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Abstract
purposeDetermine whether liver attenuation measured on dual-energy CT (DECT) virtual non-contrast examinations predicts the presence of fatty liver.
methodsSingle-institution retrospective review from 2016 to 2020 found patients with DECT and proton density fat fraction MRI (MRI PDFF) within 30 days. MRI PDFF was the reference standard for determining hepatic steatosis. Attenuation measurements from VNC and mixed 120 kVp-like images were compared to MRI PDFF in the right and left lobes. Performance of VNC was compared to measurement of the liver-spleen attenuation difference (LSAD).
results128 patients were included (69 men, 59 women) with mean age 51.6 years (range 14-98 years). > 90% of patients received CT and MRI in the emergency department or as inpatients. Median interval between DECT and MRI PDFF was 2 days (range 0-28 days). Prevalence of fatty liver using the reference standard (MRI PDFF > 6%) was 24%. Pearson correlation coefficient between VNC and MRI- DFF was -0.64 (right) and -0.68 (left, both p < 0.0001). For LSAD, correlation was - 0.43 in both lobes (p < 0.0001). Considering MRI PDFF > 6% as diagnostic of steatosis, area under the receiver operator characteristic curve (AUC) was 0.834 and 0.872 in the right and left hepatic lobes, with an optimal threshold of 54.8 HU (right) and 52.5 HU (left), yielding sensitivity/specificity of 57%/93.9% (right) and 67.9%/90% (left). For LSAD, AUC was 0.808 (right) and 0.767 (left) with optimal sensitivity/specificity of 93.3%/57.1% (right) and 78.6%/68% (left).
conclusionAttenuation measured at VNC CT was moderately correlated with liver fat content and had > 90% specificity for diagnosis of fatty liver.
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