Evidence map›Paper›PMID 35306596›Full record

ArticleEJNMMI radiopharmacy and chemistry2022

multi-patient dose synthesis of [18F]Flumazenil via a copper-mediated

Thibault Gendron, Gianluca Destro, Natan J W Straathof, Jeroen B I Sap, Florian Guibbal, Charles Vriamont, Claire Caygill, John R Atack, Andrew J Watkins, Christopher Marshall and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI radiopharmacy and chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Chemical science · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. GMP-compliant automated radiosynthesis of [EJNMMI radiopharmacy and chemistry · 2024
    Article
  6. Article
  7. Review
  8. Effective Preparation of [Molecules (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Thibault Gendron *Trasis, Rue Gilles Magnée, 90, 4430, Ans, Belgium.ORCID https://orcid.org/0000-0002-2162-3704
Gianluca Destro *Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
Natan J W StraathofChemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
Jeroen B I SapChemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
Florian GuibbalChemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
Charles VriamontTrasis, Rue Gilles Magnée, 90, 4430, Ans, Belgium.
Claire CaygillMedicines Discovery Institute, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, UK.
John R AtackMedicines Discovery Institute, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, UK.
Andrew J WatkinsWales Research and Diagnostic PET Imaging Centre, Cardiff University, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN, UK.
Christopher MarshallWales Research and Diagnostic PET Imaging Centre, Cardiff University, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN, UK.
Rebekka HuetingWales Research and Diagnostic PET Imaging Centre, Cardiff University, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN, UK.
Corentin WarnierTrasis, Rue Gilles Magnée, 90, 4430, Ans, Belgium.
Véronique GouverneurChemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK. veronique.gouverneur@chem.ox.ac.uk.
Matthew TredwellWales Research and Diagnostic PET Imaging Centre, Cardiff University, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN, UK. tredwellm@cardiff.ac.uk.ORCID http://orcid.org/0000-0002-4184-5611
University of Oxford · GBUniversity Hospital of Wales · GBCardiff University · GB

Funding

Engineering and Physical Sciences Research Council EP/R511742/1Medical Research Council MC_PC_19033
6 · The paper itself

Abstract

backgroundFlumazenil (FMZ) is a functionally silent imidazobenzodiazepine which binds to the benzodiazepine binding site of approximately 75% of the brain γ-aminobutyric acid-A receptors (GABA

resultsThe fully automated synthesis was developed on the Trasis AllinOne (AIO) platform using a single-use cassette. [

conclusionReported is a fully automated cassette-based synthesis of [

Indexed as

[18F]FlumazenilAutomationFluorine-18Good manufacturing practicePositron emission tomography

Identifiers

PMID35306596
PMCPMC8934836
OpenAlexW4221003518

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.