Evidence map›Paper›PMID 35310351›Full record

ArticleBioactive materials2022

Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery.

Patrick Rider, Željka Perić Kačarević, Akiva Elad, Drazen Tadic, Daniel Rothamel, Gerrit Sauer, Fabien Bornert, Peter Windisch, Dávid Botond Hangyási, Balint Molnar and 3 more

Abstract read
In one paragraph

Article in Bioactive materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Article
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  4. Materials advances in GTR membrane: A comprehensive review.Journal of Taibah University Medical Sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Patrick RiderDepartment of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charité - Universitätsmedizin Berlin, Aßmannshauser Straße 4-6, 14197, Berlin, Germany.
Željka Perić KačarevićDepartment of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charité - Universitätsmedizin Berlin, Aßmannshauser Straße 4-6, 14197, Berlin, Germany.
Akiva EladBotiss Biomaterials AG, Ullsteinstrasse 108, 12109, Berlin, Germany.
Drazen TadicBotiss Biomaterials AG, Ullsteinstrasse 108, 12109, Berlin, Germany.
Daniel RothamelCMF Surgery, Johannes BLA Hospital, Mönchengladbach, Germany.
Gerrit SauerCMF Surgery, Johannes BLA Hospital, Mönchengladbach, Germany.
Fabien BornertDental Clinic, University of Strasbourg, France.
Peter WindischDepartment of Periodontology, Semmelweis University, Budapest, Hungary.
Dávid Botond HangyásiDepartment of Periodontology, Semmelweis University, Budapest, Hungary.
Balint MolnarDepartment of Periodontology, Semmelweis University, Budapest, Hungary.
Emely BortelXploraytion GmbH, Bismarkstrasse 11, Berlin, Germany.
Bernhard HesseXploraytion GmbH, Bismarkstrasse 11, Berlin, Germany.
Frank WitteDepartment of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charité - Universitätsmedizin Berlin, Aßmannshauser Straße 4-6, 14197, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Barrier membranes are commonly used as part of the dental surgical technique guided bone regeneration (GBR) and are often made of resorbable collagen or non-resorbable materials such as PTFE. While collagen membranes do not provide sufficient mechanical protection of the covered bone defect, titanium reinforced membranes and non-resorbable membranes need to be removed in a second surgery. Thus, biodegradable GBR membranes made of pure magnesium might be an alternative. In this study a biodegradable pure magnesium (99.95%) membrane has been proven to have all of the necessary requirements for an optimal regenerative outcome from both a mechanical and biological perspective. After implantation, the magnesium membrane separates the regenerating bone from the overlying, faster proliferating soft tissue. During the initial healing period, the membrane maintained a barrier function and space provision, whilst retaining the positioning of the bone graft material within the defect space. As the magnesium metal corroded, it formed a salty corrosion layer and local gas cavities, both of which extended the functional lifespan of the membrane barrier capabilities. During the resorption of the magnesium metal and magnesium salts, it was observed that the membrane became surrounded and then replaced by new bone. After the membrane had completely resorbed, only healthy tissue remained. The

Indexed as

BiodegradableBone healingGBRGBR, Guided Bone RegenerationImplantMagnesiumSoft tissue healing

Identifiers

PMID35310351
PMCPMC8892166

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.