Evidence map›Paper›PMID 35310489›Full record

ArticleChemical science2022

Enhancing proline-rich antimicrobial peptide action by homodimerization: influence of bifunctional linker.

Wenyi Li, Feng Lin, Andrew Hung, Anders Barlow, Marc-Antoine Sani, Rita Paolini, William Singleton, James Holden, Mohammed Akhter Hossain, Frances Separovic and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Article
  3. Journal of clinical practice and research · 2025
    Article
  4. Exploring the additive antibacterial potential ofFrontiers in microbiology · 2025
    Article
  5. Review
  6. Proline-Rich Antimicrobial Peptides from Invertebrates.Molecules (Basel, Switzerland) · 2024
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Wenyi LiThe Bio21 Institute of Molecular Science and Biotechnology Australia.ORCID https://orcid.org/0000-0003-3584-0301
Feng LinFlorey Institute of Neuroscience and Mental Health, University of Melbourne Australia john.wade@florey.edu.au.
Andrew HungSchool of Science, RMIT University Australia.
Anders BarlowMaterials Characterization and Fabrication Platform Australia.
Marc-Antoine SaniThe Bio21 Institute of Molecular Science and Biotechnology Australia.ORCID https://orcid.org/0000-0003-3284-2176
Rita PaoliniMelbourne Dental School, Centre for Oral Health Research Australia wenyi.li@unimelb.edu.au neil.obs@unimelb.edu.au.
William SingletonMelbourne Dental School, Centre for Oral Health Research Australia wenyi.li@unimelb.edu.au neil.obs@unimelb.edu.au.
James HoldenMelbourne Dental School, Centre for Oral Health Research Australia wenyi.li@unimelb.edu.au neil.obs@unimelb.edu.au.
Mohammed Akhter HossainFlorey Institute of Neuroscience and Mental Health, University of Melbourne Australia john.wade@florey.edu.au.ORCID https://orcid.org/0000-0002-9961-0006
Frances SeparovicThe Bio21 Institute of Molecular Science and Biotechnology Australia.ORCID https://orcid.org/0000-0002-6484-2763
Neil M O'Brien-SimpsonThe Bio21 Institute of Molecular Science and Biotechnology Australia.
John D WadeFlorey Institute of Neuroscience and Mental Health, University of Melbourne Australia john.wade@florey.edu.au.ORCID https://orcid.org/0000-0002-1352-6568
Royal Dental Hospital of Melbourne · AUThe University of Melbourne · AURMIT University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antimicrobial peptides (AMPs) are host defense peptides, and unlike conventional antibiotics, they possess potent broad spectrum activities and, induce little or no antimicrobial resistance. They are attractive lead molecules for rational development to improve their therapeutic index. Our current studies examined dimerization of the

Identifiers

PMID35310489
PMCPMC8864714
OpenAlexW4210313584

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.