Evidence map›Paper›PMID 35312939›Full record

ArticleMolecular imaging and biology2022

Impact of Tumor Burden on Normal Organ Distribution in Patients Imaged with CXCR4-Targeted [

Sebastian E Serfling, Constantin Lapa, Niklas Dreher, Philipp E Hartrampf, Steven P Rowe, Takahiro Higuchi, Andreas Schirbel, Alexander Weich, Stefanie Hahner, Martin Fassnacht and 2 more

Registry-linked trialAbstract read
In one paragraph

Article in Molecular imaging and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05557708 (Biodistribution of 68Ga Pentixafor in Patients With Small Cell Lung Carcinoma), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05557708 early_phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Biodistribution of 68Ga Pentixafor in Patients With Small Cell Lung Carcinoma (SCLC)

TypeinterventionalSponsorYusuf MendaRan2026 to 2030Enrolled20ConditionsCarcinoid Tumor Lung, Neuroendocrine Tumor of the Lung, Carcinoma, Small-Cell LungArms212-Lead Pentixather, 203-Lead Pentixather SPECT/CT
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. CXCR4-targeted PET imaging of glioblastoma using [EJNMMI radiopharmacy and chemistry · 2026
    Article
  3. Article
  4. Prognostic impact of discordant lesions on [Frontiers in nuclear medicine · 2026
    Article
  5. Review
  6. Review
  7. Selective PET imaging of CXCR4 using the AlEuropean journal of nuclear medicine and molecular imaging · 2025
    Article
  8. Article
  9. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Article
  10. Review
  11. CXCR4-directed PET/CT with [European journal of nuclear medicine and molecular imaging · 2024
    Article
  12. Article
  13. Article
  14. Advances in PET Imaging of the CXCR4 Receptor: [Seminars in nuclear medicine · 2024
    Review
  15. Article
  16. Article
  17. C-X-C Motif Chemokine Receptor 4-Targeted Radioligand Therapy in Patients with Advanced T-Cell Lymphoma.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  18. CXCR4-targeted theranostics in oncology.European journal of nuclear medicine and molecular imaging · 2022
    Review
  19. Current Status ofDiagnostics (Basel, Switzerland) · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sebastian E SerflingDepartment of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacherstr. 6, Würzburg, 97080, Germany.
Constantin LapaNuclear Medicine, Medical Faculty, University of Augsburg, Augsburg, Germany.
Niklas DreherDepartment of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacherstr. 6, Würzburg, 97080, Germany.
Philipp E HartrampfDepartment of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacherstr. 6, Würzburg, 97080, Germany.
Steven P RoweThe Russell H Morgan Department of Radiology and Radiological Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Takahiro HiguchiDepartment of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacherstr. 6, Würzburg, 97080, Germany.
Andreas SchirbelDepartment of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacherstr. 6, Würzburg, 97080, Germany.
Alexander WeichDepartment of Internal Medicine II, Gastroenterology, University Hospital Würzburg, Würzburg, Germany.
Stefanie HahnerDivision of Endocrinology and Diabetes, Department of Medicine I, University Hospital Würzburg, Würzburg, Germany.
Martin FassnachtDivision of Endocrinology and Diabetes, Department of Medicine I, University Hospital Würzburg, Würzburg, Germany.
Andreas K Buck *Department of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacherstr. 6, Würzburg, 97080, Germany.
Rudolf A Werner *Department of Nuclear Medicine, University Hospital Würzburg, Oberdürrbacherstr. 6, Würzburg, 97080, Germany. werner_r1@ukw.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCXCR4-directed positron emission tomography/computed tomography (PET/CT) has been used as a diagnostic tool in patients with solid tumors. We aimed to determine a potential correlation between tumor burden and radiotracer accumulation in normal organs.

methodsNinety patients with histologically proven solid cancers underwent CXCR4-targeted [

resultsMedian SUV

conclusionsIn patients with solid tumors imaged with [

Indexed as

NeoplasmsPositron Emission Tomography Computed TomographyCoordination ComplexesGallium RadioisotopesHumansPeptides, CyclicReceptors, CXCR4Tumor Burden68Ga-pentixaforCoordination ComplexesCXCR4 protein, humanGallium RadioisotopesPeptides, CyclicReceptors, CXCR4[177Lu]/[90Y]PentixaTher[68Ga]PentixaForC-X-C motif chemokine receptor 4CXCR4EndoradiotherapyPETTheranostics

Identifiers

PMID35312939
PMCPMC9296404

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.