GuidelineNeurology2022
Stroke Prevention in Symptomatic Large Artery Intracranial Atherosclerosis Practice Advisory: Report of the AAN Guideline Subcommittee.
Open access · greenAbstract readPractice Guideline
In one paragraph
Guideline in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 3 pooled it
4.7field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Ticagrelor versus clopidogrel in dual antiplatelet therapy after minor stroke or transient ischemic attack: an updated network meta-analysis.Journal of neurology · 2024Pooled it
- Percutaneous transluminal angioplasty and stenting vs aggressive medical management on stroke or intracranial atherosclerotic stenosis: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Endovascular Therapy for Intracranial Giant Cell Arteritis : Systematic Review, Technical Considerations and the Effect of Intra-arterial Calcium Channel Blockers.Clinical neuroradiology · 2022Pooled it
- Trial
- Home-Based RESIST: Rationale and Design of a Multicenter Randomized Controlled Trial.Journal of the American Heart Association · 2026Trial
- Effect of Stenting Plus Medical Therapy vs Medical Therapy Alone on Risk of Stroke and Death in Patients With Symptomatic Intracranial Stenosis: The CASSISS Randomized Clinical Trial.JAMA · 2022 · on this mapTrial
- Efficacy and Safety of an Early Aggressive Lipid-Lowering Strategy Using Triple Therapy After Mechanical Thrombectomy.CNS drugs · 2026Article
- Article
- Balloon Passage via Microwire Navigation Technology for Severe Stenosis of Middle Cerebral Artery: A Case Report.Clinical case reports · 2026Article
- Primary versus elective percutaneous transluminal angioplasty with stenting for symptomatic intracranial atherosclerotic stenosis: a 18-centre retrospective cohort study using the pEGASUS-HPC stent.European stroke journal · 2026Article
- Association of Glucagon-like Peptide-1 Receptor Agonist Use with Stroke and Mortality Outcomes in Asymptomatic Intracranial Atherosclerotic Disease: Propensity Score-Matched Real-World Analysis.Neurology international · 2026Article
- A Segatella Copri-centered Gut Microbiota-mediated Metabolic Dysregulation Associated with Transition from Asymptomatic to Symptomatic Intracranial Atherosclerosis.Translational stroke research · 2026Article
- Comparison of pEGASUS-HPC and CREDO Heal stent systems deployed via NeuroSpeed percutaneous angioplasty balloon catheter for treatment of acute symptomatic intracranial stenosis and occlusion.Clinical neuroradiology · 2026Article
- Focal Cerebral Arteriopathy in a Young Adult.Cureus · 2026Article
- Parent Artery Disease-Related Stroke: What Is the Impact on Endovascular Treatment? A Narrative Review.Journal of clinical medicine · 2026Review
- Imaging Markers Predict the Short-Term and Long-Term Stroke Recurrence in Symptomatic Intracranial Atherosclerotic Disease.Cerebrovascular diseases extra · 2026Article
- Global Perspectives on Endovascular Treatment of Intracranial Atherosclerotic Disease.Journal of neuroendovascular therapy · 2026Review
- Observational
- Endovascular Therapy for Intracranial Atherosclerotic Stenosis: Evidence and Controversies.Journal of neuroendovascular therapy · 2026Review
- Stroke Mechanisms in Intracranial Atherosclerotic Disease: A Modified Classification System and Clinical Implications.Translational stroke research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 2 institutions in 1 country.
Tanya N TuranFrom the Department of Neurology (T.N.T., M.I.C.), Medical University of South Carolina, Charleston; Department of Neurology (O.O.Z.), Mercy Health, Toledo, OH; Department of Neurology (G.S.G.), University of Kansas, Kansas City, MO; Department of Neurology (A.C., J.G.L.), SUNY Upstate Medical University, Syracuse, NY; Department of Neurology (A.J.F.), Cleveland Medical Center, OH; Department of Neurology (L.B.G.), University of Kentucky, Lexington; Department of Neurosurgery (N.R.G.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (S.R.M., L.R.W.), University of Pennsylvania, Philadelphia; Departments of Neurology and Radiology (T.N.N.), Boston Medical Center, MA; Department of Neurology (R.S.S.), University of Alabama, Birmingham; Department of Neurosurgery (M.J.S.), Loyola University Chicago, Maywood, IL; Department of Neurology (A.B.S.), Massachusetts General Hospital, Boston; Department of Neurology (A.A.R.), Mayo Clinic, Rochester; American Academy of Neurology (M.D.O., H.S.), Minneapolis, MN; and Department of Neurosurgery (J.J.F.), University of Michigan Health-West, Grand Rapids.
Osama O ZaidatFrom the Department of Neurology (T.N.T., M.I.C.), Medical University of South Carolina, Charleston; Department of Neurology (O.O.Z.), Mercy Health, Toledo, OH; Department of Neurology (G.S.G.), University of Kansas, Kansas City, MO; Department of Neurology (A.C., J.G.L.), SUNY Upstate Medical University, Syracuse, NY; Department of Neurology (A.J.F.), Cleveland Medical Center, OH; Department of Neurology (L.B.G.), University of Kentucky, Lexington; Department of Neurosurgery (N.R.G.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (S.R.M., L.R.W.), University of Pennsylvania, Philadelphia; Departments of Neurology and Radiology (T.N.N.), Boston Medical Center, MA; Department of Neurology (R.S.S.), University of Alabama, Birmingham; Department of Neurosurgery (M.J.S.), Loyola University Chicago, Maywood, IL; Department of Neurology (A.B.S.), Massachusetts General Hospital, Boston; Department of Neurology (A.A.R.), Mayo Clinic, Rochester; American Academy of Neurology (M.D.O., H.S.), Minneapolis, MN; and Department of Neurosurgery (J.J.F.), University of Michigan Health-West, Grand Rapids.
Gary S GronsethFrom the Department of Neurology (T.N.T., M.I.C.), Medical University of South Carolina, Charleston; Department of Neurology (O.O.Z.), Mercy Health, Toledo, OH; Department of Neurology (G.S.G.), University of Kansas, Kansas City, MO; Department of Neurology (A.C., J.G.L.), SUNY Upstate Medical University, Syracuse, NY; Department of Neurology (A.J.F.), Cleveland Medical Center, OH; Department of Neurology (L.B.G.), University of Kentucky, Lexington; Department of Neurosurgery (N.R.G.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (S.R.M., L.R.W.), University of Pennsylvania, Philadelphia; Departments of Neurology and Radiology (T.N.N.), Boston Medical Center, MA; Department of Neurology (R.S.S.), University of Alabama, Birmingham; Department of Neurosurgery (M.J.S.), Loyola University Chicago, Maywood, IL; Department of Neurology (A.B.S.), Massachusetts General Hospital, Boston; Department of Neurology (A.A.R.), Mayo Clinic, Rochester; American Academy of Neurology (M.D.O., H.S.), Minneapolis, MN; and Department of Neurosurgery (J.J.F.), University of Michigan Health-West, Grand Rapids.
Marc I ChimowitzFrom the Department of Neurology (T.N.T., M.I.C.), Medical University of South Carolina, Charleston; Department of Neurology (O.O.Z.), Mercy Health, Toledo, OH; Department of Neurology (G.S.G.), University of Kansas, Kansas City, MO; Department of Neurology (A.C., J.G.L.), SUNY Upstate Medical University, Syracuse, NY; Department of Neurology (A.J.F.), Cleveland Medical Center, OH; Department of Neurology (L.B.G.), University of Kentucky, Lexington; Department of Neurosurgery (N.R.G.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (S.R.M., L.R.W.), University of Pennsylvania, Philadelphia; Departments of Neurology and Radiology (T.N.N.), Boston Medical Center, MA; Department of Neurology (R.S.S.), University of Alabama, Birmingham; Department of Neurosurgery (M.J.S.), Loyola University Chicago, Maywood, IL; Department of Neurology (A.B.S.), Massachusetts General Hospital, Boston; Department of Neurology (A.A.R.), Mayo Clinic, Rochester; American Academy of Neurology (M.D.O., H.S.), Minneapolis, MN; and Department of Neurosurgery (J.J.F.), University of Michigan Health-West, Grand Rapids.
Antonio CulebrasFrom the Department of Neurology (T.N.T., M.I.C.), Medical University of South Carolina, Charleston; Department of Neurology (O.O.Z.), Mercy Health, Toledo, OH; Department of Neurology (G.S.G.), University of Kansas, Kansas City, MO; Department of Neurology (A.C., J.G.L.), SUNY Upstate Medical University, Syracuse, NY; Department of Neurology (A.J.F.), Cleveland Medical Center, OH; Department of Neurology (L.B.G.), University of Kentucky, Lexington; Department of Neurosurgery (N.R.G.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (S.R.M., L.R.W.), University of Pennsylvania, Philadelphia; Departments of Neurology and Radiology (T.N.N.), Boston Medical Center, MA; Department of Neurology (R.S.S.), University of Alabama, Birmingham; Department of Neurosurgery (M.J.S.), Loyola University Chicago, Maywood, IL; Department of Neurology (A.B.S.), Massachusetts General Hospital, Boston; Department of Neurology (A.A.R.), Mayo Clinic, Rochester; American Academy of Neurology (M.D.O., H.S.), Minneapolis, MN; and Department of Neurosurgery (J.J.F.), University of Michigan Health-West, Grand Rapids.
Anthony J FurlanFrom the Department of Neurology (T.N.T., M.I.C.), Medical University of South Carolina, Charleston; Department of Neurology (O.O.Z.), Mercy Health, Toledo, OH; Department of Neurology (G.S.G.), University of Kansas, Kansas City, MO; Department of Neurology (A.C., J.G.L.), SUNY Upstate Medical University, Syracuse, NY; Department of Neurology (A.J.F.), Cleveland Medical Center, OH; Department of Neurology (L.B.G.), University of Kentucky, Lexington; Department of Neurosurgery (N.R.G.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (S.R.M., L.R.W.), University of Pennsylvania, Philadelphia; Departments of Neurology and Radiology (T.N.N.), Boston Medical Center, MA; Department of Neurology (R.S.S.), University of Alabama, Birmingham; Department of Neurosurgery (M.J.S.), Loyola University Chicago, Maywood, IL; Department of Neurology (A.B.S.), Massachusetts General Hospital, Boston; Department of Neurology (A.A.R.), Mayo Clinic, Rochester; American Academy of Neurology (M.D.O., H.S.), Minneapolis, MN; and Department of Neurosurgery (J.J.F.), University of Michigan Health-West, Grand Rapids.
Larry B GoldsteinFrom the Department of Neurology (T.N.T., M.I.C.), Medical University of South Carolina, Charleston; Department of Neurology (O.O.Z.), Mercy Health, Toledo, OH; Department of Neurology (G.S.G.), University of Kansas, Kansas City, MO; Department of Neurology (A.C., J.G.L.), SUNY Upstate Medical University, Syracuse, NY; Department of Neurology (A.J.F.), Cleveland Medical Center, OH; Department of Neurology (L.B.G.), University of Kentucky, Lexington; Department of Neurosurgery (N.R.G.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (S.R.M., L.R.W.), University of Pennsylvania, Philadelphia; Departments of Neurology and Radiology (T.N.N.), Boston Medical Center, MA; Department of Neurology (R.S.S.), University of Alabama, Birmingham; Department of Neurosurgery (M.J.S.), Loyola University Chicago, Maywood, IL; Department of Neurology (A.B.S.), Massachusetts General Hospital, Boston; Department of Neurology (A.A.R.), Mayo Clinic, Rochester; American Academy of Neurology (M.D.O., H.S.), Minneapolis, MN; and Department of Neurosurgery (J.J.F.), University of Michigan Health-West, Grand Rapids.ORCID 0000-0001-7747-128X
Nestor R GonzalezFrom the Department of Neurology (T.N.T., M.I.C.), Medical University of South Carolina, Charleston; Department of Neurology (O.O.Z.), Mercy Health, Toledo, OH; Department of Neurology (G.S.G.), University of Kansas, Kansas City, MO; Department of Neurology (A.C., J.G.L.), SUNY Upstate Medical University, Syracuse, NY; Department of Neurology (A.J.F.), Cleveland Medical Center, OH; Department of Neurology (L.B.G.), University of Kentucky, Lexington; Department of Neurosurgery (N.R.G.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (S.R.M., L.R.W.), University of Pennsylvania, Philadelphia; Departments of Neurology and Radiology (T.N.N.), Boston Medical Center, MA; Department of Neurology (R.S.S.), University of Alabama, Birmingham; Department of Neurosurgery (M.J.S.), Loyola University Chicago, Maywood, IL; Department of Neurology (A.B.S.), Massachusetts General Hospital, Boston; Department of Neurology (A.A.R.), Mayo Clinic, Rochester; American Academy of Neurology (M.D.O., H.S.), Minneapolis, MN; and Department of Neurosurgery (J.J.F.), University of Michigan Health-West, Grand Rapids.ORCID 0000-0002-8277-6317
Julius G LatorreFrom the Department of Neurology (T.N.T., M.I.C.), Medical University of South Carolina, Charleston; Department of Neurology (O.O.Z.), Mercy Health, Toledo, OH; Department of Neurology (G.S.G.), University of Kansas, Kansas City, MO; Department of Neurology (A.C., J.G.L.), SUNY Upstate Medical University, Syracuse, NY; Department of Neurology (A.J.F.), Cleveland Medical Center, OH; Department of Neurology (L.B.G.), University of Kentucky, Lexington; Department of Neurosurgery (N.R.G.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (S.R.M., L.R.W.), University of Pennsylvania, Philadelphia; Departments of Neurology and Radiology (T.N.N.), Boston Medical Center, MA; Department of Neurology (R.S.S.), University of Alabama, Birmingham; Department of Neurosurgery (M.J.S.), Loyola University Chicago, Maywood, IL; Department of Neurology (A.B.S.), Massachusetts General Hospital, Boston; Department of Neurology (A.A.R.), Mayo Clinic, Rochester; American Academy of Neurology (M.D.O., H.S.), Minneapolis, MN; and Department of Neurosurgery (J.J.F.), University of Michigan Health-West, Grand Rapids.
Steven R MesséFrom the Department of Neurology (T.N.T., M.I.C.), Medical University of South Carolina, Charleston; Department of Neurology (O.O.Z.), Mercy Health, Toledo, OH; Department of Neurology (G.S.G.), University of Kansas, Kansas City, MO; Department of Neurology (A.C., J.G.L.), SUNY Upstate Medical University, Syracuse, NY; Department of Neurology (A.J.F.), Cleveland Medical Center, OH; Department of Neurology (L.B.G.), University of Kentucky, Lexington; Department of Neurosurgery (N.R.G.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (S.R.M., L.R.W.), University of Pennsylvania, Philadelphia; Departments of Neurology and Radiology (T.N.N.), Boston Medical Center, MA; Department of Neurology (R.S.S.), University of Alabama, Birmingham; Department of Neurosurgery (M.J.S.), Loyola University Chicago, Maywood, IL; Department of Neurology (A.B.S.), Massachusetts General Hospital, Boston; Department of Neurology (A.A.R.), Mayo Clinic, Rochester; American Academy of Neurology (M.D.O., H.S.), Minneapolis, MN; and Department of Neurosurgery (J.J.F.), University of Michigan Health-West, Grand Rapids.
Thanh N NguyenFrom the Department of Neurology (T.N.T., M.I.C.), Medical University of South Carolina, Charleston; Department of Neurology (O.O.Z.), Mercy Health, Toledo, OH; Department of Neurology (G.S.G.), University of Kansas, Kansas City, MO; Department of Neurology (A.C., J.G.L.), SUNY Upstate Medical University, Syracuse, NY; Department of Neurology (A.J.F.), Cleveland Medical Center, OH; Department of Neurology (L.B.G.), University of Kentucky, Lexington; Department of Neurosurgery (N.R.G.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (S.R.M., L.R.W.), University of Pennsylvania, Philadelphia; Departments of Neurology and Radiology (T.N.N.), Boston Medical Center, MA; Department of Neurology (R.S.S.), University of Alabama, Birmingham; Department of Neurosurgery (M.J.S.), Loyola University Chicago, Maywood, IL; Department of Neurology (A.B.S.), Massachusetts General Hospital, Boston; Department of Neurology (A.A.R.), Mayo Clinic, Rochester; American Academy of Neurology (M.D.O., H.S.), Minneapolis, MN; and Department of Neurosurgery (J.J.F.), University of Michigan Health-West, Grand Rapids.ORCID 0000-0002-2810-1685
Rajbeer S SanghaFrom the Department of Neurology (T.N.T., M.I.C.), Medical University of South Carolina, Charleston; Department of Neurology (O.O.Z.), Mercy Health, Toledo, OH; Department of Neurology (G.S.G.), University of Kansas, Kansas City, MO; Department of Neurology (A.C., J.G.L.), SUNY Upstate Medical University, Syracuse, NY; Department of Neurology (A.J.F.), Cleveland Medical Center, OH; Department of Neurology (L.B.G.), University of Kentucky, Lexington; Department of Neurosurgery (N.R.G.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (S.R.M., L.R.W.), University of Pennsylvania, Philadelphia; Departments of Neurology and Radiology (T.N.N.), Boston Medical Center, MA; Department of Neurology (R.S.S.), University of Alabama, Birmingham; Department of Neurosurgery (M.J.S.), Loyola University Chicago, Maywood, IL; Department of Neurology (A.B.S.), Massachusetts General Hospital, Boston; Department of Neurology (A.A.R.), Mayo Clinic, Rochester; American Academy of Neurology (M.D.O., H.S.), Minneapolis, MN; and Department of Neurosurgery (J.J.F.), University of Michigan Health-West, Grand Rapids.
Michael J SchneckFrom the Department of Neurology (T.N.T., M.I.C.), Medical University of South Carolina, Charleston; Department of Neurology (O.O.Z.), Mercy Health, Toledo, OH; Department of Neurology (G.S.G.), University of Kansas, Kansas City, MO; Department of Neurology (A.C., J.G.L.), SUNY Upstate Medical University, Syracuse, NY; Department of Neurology (A.J.F.), Cleveland Medical Center, OH; Department of Neurology (L.B.G.), University of Kentucky, Lexington; Department of Neurosurgery (N.R.G.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (S.R.M., L.R.W.), University of Pennsylvania, Philadelphia; Departments of Neurology and Radiology (T.N.N.), Boston Medical Center, MA; Department of Neurology (R.S.S.), University of Alabama, Birmingham; Department of Neurosurgery (M.J.S.), Loyola University Chicago, Maywood, IL; Department of Neurology (A.B.S.), Massachusetts General Hospital, Boston; Department of Neurology (A.A.R.), Mayo Clinic, Rochester; American Academy of Neurology (M.D.O., H.S.), Minneapolis, MN; and Department of Neurosurgery (J.J.F.), University of Michigan Health-West, Grand Rapids.
Aneesh B SinghalFrom the Department of Neurology (T.N.T., M.I.C.), Medical University of South Carolina, Charleston; Department of Neurology (O.O.Z.), Mercy Health, Toledo, OH; Department of Neurology (G.S.G.), University of Kansas, Kansas City, MO; Department of Neurology (A.C., J.G.L.), SUNY Upstate Medical University, Syracuse, NY; Department of Neurology (A.J.F.), Cleveland Medical Center, OH; Department of Neurology (L.B.G.), University of Kentucky, Lexington; Department of Neurosurgery (N.R.G.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (S.R.M., L.R.W.), University of Pennsylvania, Philadelphia; Departments of Neurology and Radiology (T.N.N.), Boston Medical Center, MA; Department of Neurology (R.S.S.), University of Alabama, Birmingham; Department of Neurosurgery (M.J.S.), Loyola University Chicago, Maywood, IL; Department of Neurology (A.B.S.), Massachusetts General Hospital, Boston; Department of Neurology (A.A.R.), Mayo Clinic, Rochester; American Academy of Neurology (M.D.O., H.S.), Minneapolis, MN; and Department of Neurosurgery (J.J.F.), University of Michigan Health-West, Grand Rapids.
Lawrence R WechslerFrom the Department of Neurology (T.N.T., M.I.C.), Medical University of South Carolina, Charleston; Department of Neurology (O.O.Z.), Mercy Health, Toledo, OH; Department of Neurology (G.S.G.), University of Kansas, Kansas City, MO; Department of Neurology (A.C., J.G.L.), SUNY Upstate Medical University, Syracuse, NY; Department of Neurology (A.J.F.), Cleveland Medical Center, OH; Department of Neurology (L.B.G.), University of Kentucky, Lexington; Department of Neurosurgery (N.R.G.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (S.R.M., L.R.W.), University of Pennsylvania, Philadelphia; Departments of Neurology and Radiology (T.N.N.), Boston Medical Center, MA; Department of Neurology (R.S.S.), University of Alabama, Birmingham; Department of Neurosurgery (M.J.S.), Loyola University Chicago, Maywood, IL; Department of Neurology (A.B.S.), Massachusetts General Hospital, Boston; Department of Neurology (A.A.R.), Mayo Clinic, Rochester; American Academy of Neurology (M.D.O., H.S.), Minneapolis, MN; and Department of Neurosurgery (J.J.F.), University of Michigan Health-West, Grand Rapids.
Alejandro A RabinsteinFrom the Department of Neurology (T.N.T., M.I.C.), Medical University of South Carolina, Charleston; Department of Neurology (O.O.Z.), Mercy Health, Toledo, OH; Department of Neurology (G.S.G.), University of Kansas, Kansas City, MO; Department of Neurology (A.C., J.G.L.), SUNY Upstate Medical University, Syracuse, NY; Department of Neurology (A.J.F.), Cleveland Medical Center, OH; Department of Neurology (L.B.G.), University of Kentucky, Lexington; Department of Neurosurgery (N.R.G.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (S.R.M., L.R.W.), University of Pennsylvania, Philadelphia; Departments of Neurology and Radiology (T.N.N.), Boston Medical Center, MA; Department of Neurology (R.S.S.), University of Alabama, Birmingham; Department of Neurosurgery (M.J.S.), Loyola University Chicago, Maywood, IL; Department of Neurology (A.B.S.), Massachusetts General Hospital, Boston; Department of Neurology (A.A.R.), Mayo Clinic, Rochester; American Academy of Neurology (M.D.O., H.S.), Minneapolis, MN; and Department of Neurosurgery (J.J.F.), University of Michigan Health-West, Grand Rapids.
Mary Dolan O'BrienFrom the Department of Neurology (T.N.T., M.I.C.), Medical University of South Carolina, Charleston; Department of Neurology (O.O.Z.), Mercy Health, Toledo, OH; Department of Neurology (G.S.G.), University of Kansas, Kansas City, MO; Department of Neurology (A.C., J.G.L.), SUNY Upstate Medical University, Syracuse, NY; Department of Neurology (A.J.F.), Cleveland Medical Center, OH; Department of Neurology (L.B.G.), University of Kentucky, Lexington; Department of Neurosurgery (N.R.G.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (S.R.M., L.R.W.), University of Pennsylvania, Philadelphia; Departments of Neurology and Radiology (T.N.N.), Boston Medical Center, MA; Department of Neurology (R.S.S.), University of Alabama, Birmingham; Department of Neurosurgery (M.J.S.), Loyola University Chicago, Maywood, IL; Department of Neurology (A.B.S.), Massachusetts General Hospital, Boston; Department of Neurology (A.A.R.), Mayo Clinic, Rochester; American Academy of Neurology (M.D.O., H.S.), Minneapolis, MN; and Department of Neurosurgery (J.J.F.), University of Michigan Health-West, Grand Rapids.
Heather SilsbeeFrom the Department of Neurology (T.N.T., M.I.C.), Medical University of South Carolina, Charleston; Department of Neurology (O.O.Z.), Mercy Health, Toledo, OH; Department of Neurology (G.S.G.), University of Kansas, Kansas City, MO; Department of Neurology (A.C., J.G.L.), SUNY Upstate Medical University, Syracuse, NY; Department of Neurology (A.J.F.), Cleveland Medical Center, OH; Department of Neurology (L.B.G.), University of Kentucky, Lexington; Department of Neurosurgery (N.R.G.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (S.R.M., L.R.W.), University of Pennsylvania, Philadelphia; Departments of Neurology and Radiology (T.N.N.), Boston Medical Center, MA; Department of Neurology (R.S.S.), University of Alabama, Birmingham; Department of Neurosurgery (M.J.S.), Loyola University Chicago, Maywood, IL; Department of Neurology (A.B.S.), Massachusetts General Hospital, Boston; Department of Neurology (A.A.R.), Mayo Clinic, Rochester; American Academy of Neurology (M.D.O., H.S.), Minneapolis, MN; and Department of Neurosurgery (J.J.F.), University of Michigan Health-West, Grand Rapids. guidelines@aan.com.
Jeffrey J FletcherFrom the Department of Neurology (T.N.T., M.I.C.), Medical University of South Carolina, Charleston; Department of Neurology (O.O.Z.), Mercy Health, Toledo, OH; Department of Neurology (G.S.G.), University of Kansas, Kansas City, MO; Department of Neurology (A.C., J.G.L.), SUNY Upstate Medical University, Syracuse, NY; Department of Neurology (A.J.F.), Cleveland Medical Center, OH; Department of Neurology (L.B.G.), University of Kentucky, Lexington; Department of Neurosurgery (N.R.G.), Cedars-Sinai Medical Center, Los Angeles, CA; Department of Neurology (S.R.M., L.R.W.), University of Pennsylvania, Philadelphia; Departments of Neurology and Radiology (T.N.N.), Boston Medical Center, MA; Department of Neurology (R.S.S.), University of Alabama, Birmingham; Department of Neurosurgery (M.J.S.), Loyola University Chicago, Maywood, IL; Department of Neurology (A.B.S.), Massachusetts General Hospital, Boston; Department of Neurology (A.A.R.), Mayo Clinic, Rochester; American Academy of Neurology (M.D.O., H.S.), Minneapolis, MN; and Department of Neurosurgery (J.J.F.), University of Michigan Health-West, Grand Rapids.
SUNY Upstate Medical University · USMedical University of South Carolina · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesTo review treatments for reducing the risk of recurrent stroke or death in patients with symptomatic intracranial atherosclerotic arterial stenosis (sICAS).
methodsThe development of this practice advisory followed the process outlined in the American Academy of Neurology MAJOR RECOMMENDATIONS: Clinicians should recommend aspirin 325 mg/d for long-term prevention of stroke and death and should recommend adding clopidogrel 75 mg/d to aspirin for up to 90 days to further reduce stroke risk in patients with severe (70%-99%) sICAS who have low risk of hemorrhagic transformation. Clinicians should recommend high-intensity statin therapy to achieve a goal low-density lipoprotein cholesterol level <70 mg/dL, a long-term blood pressure target of <140/90 mm Hg, at least moderate physical activity, and treatment of other modifiable vascular risk factors for patients with sICAS. Clinicians should not recommend percutaneous transluminal angioplasty and stenting for stroke prevention in patients with moderate (50%-69%) sICAS or as the initial treatment for stroke prevention in patients with severe sICAS. Clinicians should not routinely recommend angioplasty alone or indirect bypass for stroke prevention in patients with sICAS outside clinical trials. Clinicians should not recommend direct bypass for stroke prevention in patients with sICAS. Clinicians should counsel patients about the risks of percutaneous transluminal angioplasty and stenting and alternative treatments if one of these procedures is being contemplated.
Indexed as
Intracranial ArteriosclerosisStrokeArteriesAspirinClopidogrelHumansAspirinClopidogrel
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.