ArticleEmerging microbes & infections2022
Adaptive evolution of West Nile virus facilitated increased transmissibility and prevalence in New York State.
Article in Emerging microbes & infections, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Human West Nile virus infection: a meta-analysis of recent global data (2019-24).Journal of global health · 2025Pooled it
- Metaviromic profiling of mosquito excreta using superhydrophobic collection devices expands the known RNA virome of North America.Microbiology spectrum · 2026Article
- Evolutionary history of Jamestown Canyon virus reveals complex multi-vector ecology.Current biology : CB · 2026Article
- Understanding patterns of variant emergence and spread in an ongoing epidemic.medRxiv : the preprint server for health sciences · 2026Article
- Mechanistic characterization of the antiviral effects of nordihydroguaiaretic acid against West Nile virus.Virology journal · 2026Article
- North American Culex pipiens mosquitoes are competent for Usutu virus transmission.Npj viruses · 2026Article
- Evolutionary history of Jamestown Canyon virus disentangles complex multi-vector ecology.bioRxiv : the preprint server for biology · 2026Article
- RNA metagenomic profiling of mosquito viromes associated with Vector-Borne diseases in Quebec, Canada.PloS one · 2026Article
- Vector Potential Index: Bridging Competence and Contribution as an Integrative Measure of Relative Transmission Capability.Ecology and evolution · 2026Article
- Genomic characterization of a severe West Nile Virus transmission season using a single reaction amplicon sequencing approach.PLoS neglected tropical diseases · 2026Article
- The emergence of NY10: insights into the 2012 West Nile Virus outbreak in the United States.Virus evolution · 2025Article
- Population-specific thermal responses contribute to regional variability in arbovirus transmission with changing climates.iScience · 2024Article
- The potential role of the Asian bush mosquito Aedes japonicus as spillover vector for West Nile virus in the Netherlands.Parasites & vectors · 2024Article
- Surveillance and Genetic Analysis of Jamestown Canyon Virus in New York State: 2001-2022.The American journal of tropical medicine and hygiene · 2023Article
- Article
- Patterns of West Nile Virus in the Northeastern United States Using Negative Binomial and Mechanistic Trait-Based Models.GeoHealth · 2023Article
- An advanced sequence clustering and designation workflow reveals the enzootic maintenance of a dominant West Nile virus subclade in Germany.Virus evolution · 2023Article
- Rapid spread of a new West Nile virus lineage 1 associated with increased risk of neuroinvasive disease during a large outbreak in northern Italy, 2022: One Health analysis.Journal of travel medicine · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
West Nile virus (WNV; Flavivirus, Flaviviridae) was introduced to New York State (NYS) in 1999 and rapidly expanded its range through the continental United States (US). Apart from the displacement of the introductory NY99 genotype with the WN02 genotype, there has been little evidence of adaptive evolution of WNV in the US. WNV NY10, characterized by shared amino acid substitutions R1331K and I2513M, emerged in 2010 coincident with increased WNV cases in humans and prevalence in mosquitoes. Previous studies demonstrated an increase in frequency of NY10 strains in NYS and evidence of positive selection. Here, we present updated surveillance and sequencing data for WNV in NYS and investigate if NY10 genotype strains are associated with phenotypic change consistent with an adaptive advantage. Results confirm a significant increase in prevalence in mosquitoes though 2018, and updated sequencing demonstrates a continued dominance of NY10. We evaluated NY10 strains in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.