Evidence map›Paper›PMID 35318654›Full record

ReviewBritish journal of pharmacology2022

Structural perspectives on the mechanism of signal activation, ligand selectivity and allosteric modulation in angiotensin receptors: IUPHAR Review 34.

Khuraijam Dhanachandra Singh, Sadashiva S Karnik

Open access · greenAbstract readReview
In one paragraph

Review in British journal of pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. The Angiotensin ATPharmacological reviews · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Khuraijam Dhanachandra SinghDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland Clinic, Cleveland, Ohio, USA.
Sadashiva S KarnikDepartment of Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland Clinic, Cleveland, Ohio, USA.
Case Western Reserve University · US

Funding

Modulation of Protective RAS-GPCR Pathways in Aortic DiseaseR01HL142091 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI KARNIK, SADASHIVA S · 2018 to 2021
$2.6M
Structure-Guided Studied of GPCRs of RASR01HL132351 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI KARNIK, SADASHIVA S · 2017 to 2019
$1.6M
Structure-Guided Analysis of Mechanisms of AT1R FunctionsR56HL132351 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI KARNIK, SADASHIVA S · 2016 to 2016
$548k
NHLBI NIH HHS R01 HL132351NHLBI NIH HHS R01 HL142091NHLBI NIH HHS R56 HL132351
6 · The paper itself

Abstract

Functional advances have guided our knowledge of physiological and fatal pathological mechanisms of the hormone angiotensin II (AngII) and its antagonists. Such studies revealed that tissue response to a given dose of the hormone or its antagonist depends on receptors that engage the ligand. Thus, we need to know much more about the structures of receptor-ligand complexes at high resolution. Recently, X-ray structures of both AngII receptors (AT

Indexed as

Angiotensin IIReceptor, Angiotensin, Type 1LigandsReceptor, Angiotensin, Type 2Angiotensin IILigandsReceptor, Angiotensin, Type 1Receptor, Angiotensin, Type 2allosteric modulationAngIIAT1 receptorAT2 receptorautoantibodyGPCRG proteinligand selectivityβ-arrestin

Identifiers

PMID35318654
PMCPMC9398925
OpenAlexW4221039918

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.