Evidence map›Paper›PMID 35318857›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2022

Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation.

Jiyuan Chen, Marisela Rodriguez, Jinrui Miao, Jing Liao, Pritesh P Jain, Manjia Zhao, Tengteng Zhao, Aleksandra Babicheva, Ziyi Wang, Sophia Parmisano and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Piezo1-specific deletion in macrophage attenuates radiation-induced lung injury progression in mice.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  6. Piezo channels in tumors.Journal of cancer research and clinical oncology · 2026
    Review
  7. Pharmaceuticals (Basel, Switzerland) · 2026
    Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. SETD2 drives METTL14-mediated mCellular and molecular life sciences : CMLS · 2025
    Article
  17. Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 2 institutions in 2 countries.

Jiyuan ChenSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California.
Marisela RodriguezSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California.
Jinrui MiaoState Key Laboratory of Respiratory Disease and First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Jing LiaoState Key Laboratory of Respiratory Disease and First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Pritesh P JainSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California.
Manjia ZhaoSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California.
Tengteng ZhaoSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California.
Aleksandra BabichevaSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California.
Ziyi WangSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California.
Sophia ParmisanoSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California.
Ryan PowersSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California.
Moreen MattiSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California.
Cole PaquinSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California.
Zahra SoroureddinSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California.
John Y-J ShyyDivision of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, La Jolla, California.
Patricia A ThistlethwaiteDivision of Cardiothoracic Surgery, Department of Surgery, University of California, San Diego, La Jolla, California.
Ayako MakinoDivision of Endocrinology and Metabolism, Department of Medicine, University of California, San Diego, La Jolla, California.
Jian WangSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California.
Jason X-J YuanSection of Physiology, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of California, San Diego, La Jolla, California.ORCID 0000-0002-0685-4862
University of California San Diego · USFirst Affiliated Hospital of Guangzhou Medical University · CN

Funding

Ion Channels and Membrane Receptors in Pulmonary Arterial HypertensionR35HL135807 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YUAN, JASON X J · 2017 to 2023
$5.6M
Molecular Mechanisms of Pulmonary HypertensionR01HL070852 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI THISTLETHWAITE, PATRICIA A · 2002 to 2011
$3.1M
The Role of Adaptor Protein Disabled-2 in Maintaining Endothelial Cell Function in AtherosclerosisR01HL162367 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CHEN, HONG, SHI, JINJUN · 2022 to 2025
$3.0M
Role of Gap Junction in Hypoxia-induced Pulmonary HypertensionR01HL146764 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MAKINO, AYAKO · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL070852NHLBI NIH HHS R01 HL146764NHLBI NIH HHS R01 HL162367NHLBI NIH HHS R35 HL135807
6 · The paper itself

Abstract

Concentric pulmonary vascular wall thickening due partially to increased pulmonary artery (PA) smooth muscle cell (PASMC) proliferation contributes to elevating pulmonary vascular resistance (PVR) in patients with pulmonary hypertension (PH). Although pulmonary vasoconstriction may be an early contributor to increasing PVR, the transition of contractile PASMCs to proliferative PASMCs may play an important role in the development and progression of pulmonary vascular remodeling in PH. A rise in cytosolic Ca

Indexed as

Hypertension, PulmonaryPulmonary ArteryAnimalsCalcium SignalingCell ProliferationCells, CulturedHumansIon ChannelsMembrane ProteinsMuscle, Smooth, VascularMyocytes, Smooth MuscleRatsVascular RemodelingIon ChannelsMembrane ProteinsPIEZO1 protein, humanPiezo1 protein, ratmechanosensitive channelphenotypic transitionPiezo1pulmonary hypertensionsmooth muscle cell

Identifiers

PMID35318857
PMCPMC9076422
OpenAlexW4220814084

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.