ArticleScience translational medicine2022
Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Integrative Mapping of Regulatory Variation in African American Hepatocytes Using Colocalization and MPRA: Toward Precision Drug Response.Research square · 2026Article
- Activation of IRF3 in cardiomyocytes impairs mitochondrial oxidative function through PGC-1α inhibition and drives heart failure.Nature communications · 2026Article
- DMH1 improves palmitic acid-Induced insulin resistance in cardiomyocytes via PP2A inhibition and AKT/AMPK signaling activation.Scientific reports · 2026Article
- Correlation Analysis Between Obesity Index and Glycosylated Hemoglobin Level in Type 2 Diabetes Patients: A Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Hepatic KLF9 Deficiency Inhibits Dehydroepiandrosterone (DHEA)-Induced Polycystic Ovary Syndrome via Liver-Ovary Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Population Cohort-Validated PMToxics · 2025Article
- Celastrol targets CKB-mediated futile creatine cycle in human brown adipocytes thermogenesis.Metabolism open · 2025Article
- IRF8 aggravates nonalcoholic fatty liver disease via BMAL1/PPARγ axis.Genes & diseases · 2025Article
- Unveiling the crossroads of STING signaling pathway and metabolic reprogramming: the multifaceted role of the STING in the TME and new prospects in cancer therapies.Cell communication and signaling : CCS · 2025Review
- The multiple roles of interferon regulatory factor family in health and disease.Signal transduction and targeted therapy · 2024Review
- Transcriptional control of metabolism by interferon regulatory factors.Nature reviews. Endocrinology · 2024Review
- IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease.Journal of neuroinflammation · 2024Article
- Transitions in chromatin conformation shaped by fatty acids and the circadian clock underlie hepatic transcriptional reorganization in obese mice.Cellular and molecular life sciences : CMLS · 2024Article
- The Role of Interferon Regulatory Factors in Liver Diseases.International journal of molecular sciences · 2024Review
- Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels.Nature communications · 2024Article
- Sexual dimorphism of circadian liver transcriptome.iScience · 2024Article
- IRF3 regulates neuroinflammatory responses and the expression of genes associated with Alzheimer's disease.bioRxiv : the preprint server for biology · 2024Article
- Hepatocyte GPCR signaling regulates IRF3 to control hepatic stellate cell transdifferentiation.Cell communication and signaling : CCS · 2024Article
- The role of immunity in insulin resistance in patients with polycystic ovary syndrome.Frontiers in endocrinology · 2024Review
- Unraveling the cGAS/STING signaling mechanism: impact on glycerolipid metabolism and diseases.Frontiers in medicine · 2024Review
Corrections and comments
- Commented on by
Authors and funding
27 authors at 11 institutions in 6 countries.
Suraj J PatelDivision of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Nan LiuHarvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-8314-0900
Sam PiakerDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.ORCID 0000-0002-4738-5935
Anton GulkoDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.ORCID 0000-0003-3471-9665
Maynara L AndradeDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Frankie D HeywardDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.ORCID 0000-0003-1722-5129
Tyler SermersheimDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Nufar EdingerDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.ORCID 0000-0001-7635-791X
Harini SrinivasanDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.ORCID 0000-0003-3834-424X
Margo P EmontDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.ORCID 0000-0001-9873-2784
Gregory P WestcottDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.ORCID 0000-0002-4321-3992
Jay LutherDivision of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.
Raymond T ChungDivision of Gastroenterology, Massachusetts General Hospital, Boston, MA 02114, USA.ORCID 0000-0001-7587-718X
Shuai YanDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.ORCID 0000-0003-0650-1837
Manju KumariDepartment of Cardiology, Internal Medicine III, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0003-1968-2462
Reeby ThomasImmunology and Microbiology Department, Dasman Diabetes Institute, Kuwait City, Kuwait.ORCID 0000-0001-9933-0285
Yann DeleyeDuke Molecular Physiology Institute and Division of Endocrinology, Metabolism and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0002-8545-679X
André TchernofInstitut Universitaire de Cardiologie and Pneumologie de Québec-Université Laval (IUCPQ-UL), Québec City, Canada.ORCID 0000-0002-2587-1000
Phillip J WhiteDuke Molecular Physiology Institute and Division of Endocrinology, Metabolism and Nutrition, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.ORCID 0000-0002-0957-425X
Guido A BaselliDepartment of Pathophysiology and Transplantation, Universita degli Studi di Milano, Milan, Italy.ORCID 0000-0002-0234-6828
Marica MeroniGeneral Medicine and Metabolic Diseases, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.ORCID 0000-0002-4161-4178
Dario F De JesusHarvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-8826-9095
Rasheed AhmadImmunology and Microbiology Department, Dasman Diabetes Institute, Kuwait City, Kuwait.ORCID 0000-0001-5746-0743
Rohit N KulkarniHarvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-5029-6119
Luca ValentiDepartment of Pathophysiology and Transplantation, Universita degli Studi di Milano, Milan, Italy.ORCID 0000-0001-8909-0345
Linus TsaiDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.ORCID 0000-0002-0134-6949
Evan D RosenDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.
Beth Israel Deaconess Medical Center · USBroad Institute · USDasman Diabetes Institute · KWDuke University · USMassachusetts General Hospital · USUniversity of Milan · ITBrigham and Women's Hospital · USFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITHarvard University · USHeidelberg University · DEInstitut universitaire de cardiologie et de pneumologie de Québec · CA
Funding
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI HU, FRANK B · 1992 to 2021
$25.0MVanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9MRole of IGF-1 and Insulin Receptors Beta-Cell SurvivalR01DK067536 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 2004 to 2026
$8.0MINTEGRATED ENDOCRINE &METABOLIC RESEARCH TRAININGT32DK007516 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BARBARA B. KAHN · 1986 to 2026
$6.8MRole of IRF3 in Energy and Glucose HomeostasisR01DK102170 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ROSEN, EVAN D · 2015 to 2024
$5.1MTranscriptional Mechanisms of Human Insulin ResistanceR01DK102173 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ROSEN, EVAN D · 2015 to 2022
$4.4MREGULATION OF NUTRIENT HOMEOSTASIS BY IRF4R01DK085171 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ROSEN, EVAN D · 2010 to 2018
$3.7MTGFbeta-mediated Transcriptional Reprogramming of Mature Adipocytes in ObesityR01DK113669 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ROSEN, EVAN D · 2017 to 2020
$2.2MInterrogation of dynamic RNA modifications in beta cells in type 1 diabetesUC4DK116278 · NIDDK · JOSLIN DIABETES CENTER · PI HE, CHUAN, KULKARNI, ROHIT N. · 2017 to 2017
$1.9MIdentifying an immunoregulatory axis for FGF21 in alcohol consumptionR01AA031460 · NIAAA · UT SOUTHWESTERN MEDICAL CENTER · PI Suraj J Patel · 2024 to 2026
$1.6MInnate immune regulation of hepatic insulin sensitivity and metabolismK08DK125762 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI PATEL, SURAJ J · 2020 to 2024
$826kInterrogating the role of m6A mRNA methylation in the aging of the β-cell and diabetesR00DK135927 · NIDDK · UNIVERSITY OF CHICAGO · PI Dario F De Jesus · 2025 to 2026
$498kNIAAA NIH HHS R01 AA031460NIDDK NIH HHS K08 DK125762NIDDK NIH HHS K99 DK135927NIDDK NIH HHS P30 DK046200NIDDK NIH HHS R00 DK135927NIDDK NIH HHS R01 DK067536NIDDK NIH HHS R01 DK085171NIDDK NIH HHS R01 DK102170NIDDK NIH HHS R01 DK102173NIDDK NIH HHS R01 DK113669NIDDK NIH HHS T32 DK007516NIDDK NIH HHS U24 DK059637NIDDK NIH HHS UC4 DK116278
Abstract
Inflammation has profound but poorly understood effects on metabolism, especially in the context of obesity and nonalcoholic fatty liver disease (NAFLD). Here, we report that hepatic interferon regulatory factor 3 (IRF3) is a direct transcriptional regulator of glucose homeostasis through induction of
Indexed as
Insulin ResistanceNon-alcoholic Fatty Liver DiseaseAnimalsInterferon Regulatory Factor-3MiceObesityInterferon Regulatory Factor-3Irf3 protein, mouse
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.