Evidence map›Paper›PMID 35320609›Full record

ArticleLasers in surgery and medicine2022

Photo-mediated ultrasound therapy for the treatment of retinal neovascularization in rabbit eyes.

Yu Qin, Yixin Yu, Julia Fu, Mingyang Wang, Xinmai Yang, Xueding Wang, Yannis M Paulus

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Lasers in surgery and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Cutaneous Hypervascularization Treatment Using Photo-Mediated Ultrasound Therapy.JID innovations : skin science from molecules to population health · 2023
    Article
  4. Article
  5. A review on photo-mediated ultrasound therapy.Experimental biology and medicine (Maywood, N.J.) · 2023
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Yu QinDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-4196-9291
Yixin YuDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA.
Julia FuDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA.
Mingyang WangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-4076-1643
Xinmai YangInstitute for Bioengineering Research and Department of Mechanical Engineering, University of Kansas, Lawrence, Kansas, USA.
Xueding WangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Yannis M PaulusDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-0615-628X
University of Michigan · USCentral South University · CNTongji University · CNUniversity of Kansas · US

Funding

VIVARIUM MODULEP30EY007003 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Antonetti · 1987 to 2026
$17.6M
Precisely removing microvessels by photo-mediated ultrasound therapyR01EY029489 · NEI · UNIVERSITY OF KANSAS LAWRENCE · PI YANG, XINMAI · 2018 to 2021
$1.8M
Real-time In Vivo Visualization of the Molecular Processes in Choroidal NeovascularizationK08EY027458 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PAULUS, YANNIS MANTAS · 2018 to 2021
$898k
Novel Nanosecond Laser and Ultrasound to Selectively Treat Eye Blood VesselsR41EY031219 · NEI · PHOTOSONOX LLC · PI PAULUS, YANNIS MANTAS · 2020 to 2020
$225k
NEI NIH HHS K08 EY027458NEI NIH HHS P30 EY007003NEI NIH HHS R01 EY029489NEI NIH HHS R41 EY031219
6 · The paper itself

Abstract

objectivesRetinal neovascularization (RNV) is the growth of abnormal microvessels on the retinal surface and into the vitreous, which can lead to severe vision loss. By combining relatively low-intensity ultrasound and nanosecond-pulse-duration laser, we developed a novel treatment method, namely photo-mediated ultrasound therapy (PUT), which holds a potential to remove RNV with minimal or no damage to the adjacent tissues.

methodsRNV was created in both albino and pigmented rabbits (n = 10) through a single intravitreal injection with DL-α-aminoadipic acid. RNV was treated with PUT 8 weeks postinjection. After PUT treatment, animals were evaluated longitudinally for up to 6 weeks. Treatment outcomes were evaluated through fundus photography, red-free fundus photography, fluorescein angiography (FA), and histopathology.

resultsIn both albino and pigmented rabbits, there were no leakage in the treatment area immediately after PUT treatment as demonstrated by FA, indicating the cessation of blood perfusion of the RNV in the treated area. The fluorescence leakage did not recover in albino rabbits during the 6-week posttreatment monitoring period, and only 9.9 ± 9.8% of the neovascularization remained at the end of 6 weeks. In the pigmented rabbits, the fluorescence leakage partially returned, but the level of leakage decreased over time during the 6-week posttreatment monitoring period, and only 10.8 ± 9.8% of the neovascularization remained at the end of 6 weeks. Histology demonstrated removal of vasculature without damage to the surrounding neurosensory retina.

conclusionsThese results demonstrate that PUT could precisely remove RNV without damage to the surrounding neurosensory retina in both rabbit strains.

Indexed as

Retinal NeovascularizationUltrasonic TherapyAnimalsFluorescein AngiographyIntravitreal InjectionsRabbitsRetinaangiogenesislaserphoto-mediated ultrasound therapyretinal neovascularizationultrasound

Identifiers

PMID35320609
PMCPMC9314838
OpenAlexW4220876327

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.