ReviewInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2022
The WHO Global Tuberculosis 2021 Report - not so good news and turning the tide back to End TB.
Review in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06875336 (A Multicentric Cohort and Biomarker Study for Improved Care of Patients with Extrapulmonary Tuberculosis), which is not on this map. Cited by 223 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicentric Cohort and Biomarker Study for Improved Care of Patients with Extrapulmonary Tuberculosis
Who cites it
223 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Prevalence and contributing factors of drug-resistant tuberculosis (DR-TB) in iran: a systematic review.BMC infectious diseases · 2025Pooled it
- Prevalence of pulmonary tuberculosis and associated factors among adults living with HIV/AIDS in Ethiopia, systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Pooled it
- Weak Localization of Radiographic Manifestations in Pulmonary Tuberculosis from Chest X-ray: A Systematic Review.Sensors (Basel, Switzerland) · 2023Pooled it
- Outlook for CRISPR-based tuberculosis assays now in their infancy.Frontiers in immunology · 2023Pooled it
- Towards ending tuberculosis in South Africa: an uncertainty analysis of the programmes and factors most critical to future declines.Global health action · 2026Article
- Determinants of BCG vaccine coverage among 0-2 months aged Somali children: Promoting equality in vaccination.Human vaccines & immunotherapeutics · 2026Article
- Can Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis be Treated More Successfully?Public health challenges · 2026Article
- Data-driven model analysis of the impact of environmental and socioeconomic factors on tuberculosis incidence.Infectious Disease Modelling · 2026Article
- Tuberculosis (TB) service utilisation pre and peri-COVID-19 restrictions in Johannesburg, Gauteng.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2026Article
- Profiling the disease burden in Teso subregion during community-based medical education and research services at Soroti University: a prospective study protocol.Archives of public health = Archives belges de sante publique · 2026Article
- Cytochrome P450-Mediated Metabolism of AntimycobacterialACS infectious diseases · 2026Article
- A scoping review of interventions in childhood tuberculosis prevention and treatment.Public health in practice (Oxford, England) · 2026Review
- Sequence-encoded determinants of regional mutational plasticity: comparative analysis of PE_PGRS genes in Mycobacterium tuberculosis and other bacteria.Scientific reports · 2026Article
- Epidemiological trajectories and predictive modeling of latent tuberculosis prevalence in South Asia: an in-depth global burden of disease analysis (1990-2021) with advanced forecasting to 2050.Journal of clinical tuberculosis and other mycobacterial diseases · 2026Article
- The diagnostic yield of brushing versus non-brushing bronchoalveolar lavage fluid for Xpert MTB/RIF in patients with suspected tuberculosis: a prospective self-controlled study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Investigation of sputum volatiles to classify active tuberculosis: A pilot study.Tuberculosis (Edinburgh, Scotland) · 2026Article
- Trends and determinants of tuberculosis incidence in Turkey: A secondary data analysis.Medicine · 2026Article
- Comparison of Liquid Chromatography- and Nano-Electrospray Ionization-Mass Spectrometry Approaches for Single-Cell Metabolomics.Analytical chemistry · 2026Article
- MPT64 antigen-induced immune responses as a novel diagnostic tool for tuberculosis.Microbiology spectrum · 2026Article
163 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo review the data presented in the 2021 WHO global TB report and discuss the current constraints in the global response. INTRODUCTION AND
methodsThe WHO global TB reports, consolidate TB data from countries and provide up to date assessment of the global TB epidemic. We reviewed the data presented in the 2021 report.
resultsWe noted that the 2021 WHO global TB report presents a rather grim picture on the trajectory of the global epidemic of TB including a stagnation in the annual decline in TB incidence, a decline in TB notifications and an increase in estimated TB deaths. All the targets set at the 2018 United Nations High Level Meeting on TB were off track. INTERPRETATION AND
conclusionThe sub-optimal global performance on achieving TB control targets in 2020 is attributed to the on-going COVID-19 pandemic, however, TB programs were already off track well before the onset of the pandemic, suggesting that the pandemic amplified an already fragile global TB response. We emphasize that ending the global TB epidemic will require bold leadership, optimization of existing interventions, widespread coverage, addressing social determinants of TB and importantly mobilization of adequate funding required for TB care and prevention.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.